2. Apoptosis
  3. Apoptosis
  4. AK-778-XXMU

AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth.

For research use only. We do not sell to patients.

AK-778-XXMU Chemical Structure

AK-778-XXMU Chemical Structure

CAS No. : 1227045-76-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 185 In-stock
25 mg USD 380 In-stock
50 mg USD 600 In-stock
100 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

AK-778-XXMU Related Antibodies

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Description

AK-778-XXMU is a potent inhibitor of DNA Binding 2 (ID2) antagonist with a KD of 129 nM. AK-778-XXMU can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and more importantly, slow down the tumor growth[1].

Molecular Weight

392.83

Formula

C22H17ClN2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=CC=N1)CC2(C(N(C3=C2C=CC=C3)CC4=CC=CC(Cl)=C4)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5456 mL 12.7282 mL 25.4563 mL
5 mM 0.5091 mL 2.5456 mL 5.0913 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5456 mL 12.7282 mL 25.4563 mL 63.6408 mL
5 mM 0.5091 mL 2.5456 mL 5.0913 mL 12.7282 mL
10 mM 0.2546 mL 1.2728 mL 2.5456 mL 6.3641 mL
15 mM 0.1697 mL 0.8485 mL 1.6971 mL 4.2427 mL
20 mM 0.1273 mL 0.6364 mL 1.2728 mL 3.1820 mL
25 mM 0.1018 mL 0.5091 mL 1.0183 mL 2.5456 mL
30 mM 0.0849 mL 0.4243 mL 0.8485 mL 2.1214 mL
40 mM 0.0636 mL 0.3182 mL 0.6364 mL 1.5910 mL
50 mM 0.0509 mL 0.2546 mL 0.5091 mL 1.2728 mL
60 mM 0.0424 mL 0.2121 mL 0.4243 mL 1.0607 mL
80 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.7955 mL
100 mM 0.0255 mL 0.1273 mL 0.2546 mL 0.6364 mL
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AK-778-XXMU Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK-778-XXMU1227045-76-2Apoptosisinhibitor of DNA Binding 2ID2cell migrationinvasionglioma cell linestumor growthInhibitorinhibitorinhibit

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