AL-611

Cat. No.: HY-145374: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AL-611 is an HCV NS5B polymerase inhibitor (EC₅₀ = 5 nM).

For research use only. We do not sell to patients.

AL-611 Chemical Structure

CAS No. : 2481279-61-0

Size	Price	Stock
1 mg	USD 600	Ask For Quote & Lead Time
5 mg	USD 1500	Ask For Quote & Lead Time
10 mg	USD 2400	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of AL-611:

Antiviral agent 63 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

AL-611 is an HCV NS5B polymerase inhibitor (EC₅₀ = 5 nM).

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	> 100 μM Compound: 40	Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human A549 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HeLa	CC₅₀	> 100 μM Compound: 40	Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HeLa cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
HepG2	CC₅₀	> 100 μM Compound: 40	Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HepG2 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	> 100 μM Compound: 40	Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human HuH7 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
Huh-7	CC₅₀	> 100 μM Compound: 40	Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay Cytotoxicity against human HuH7 cells infected with HCV con1 subgenomic replicon assessed as reduction in cell viability measured after 3 days by CellTiter-blue cell viability assay	[PMID: 32816483]
Huh-7	EC₅₀	0.014 μM Compound: 40	Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis Antiviral activity against HCV con1 subgenomic replicon infected in human HuH7 cells assessed as reduction in viral RNA level by qRT-PCR analysis	[PMID: 32816483]
MT4	CC₅₀	92 μM Compound: 40	Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human MT4 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]
U-937	CC₅₀	10 μM Compound: 40	Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay Cytotoxicity against human U937 cells incubated for 8 days by cellTiter-Glo assay	[PMID: 32816483]

Molecular Weight

614.54

Formula

C₂₅H₃₃F₂N₆O₈P

CAS No.

2481279-61-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1([C@](O[C@@](F)([C@H]1O)CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)([H])N3C4=NC(N)=NC(OCC)=C4N=C3)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (203.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6272 mL	8.1362 mL	16.2723 mL
5 mM	0.3254 mL	1.6272 mL	3.2545 mL
10 mM	0.1627 mL	0.8136 mL	1.6272 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.41%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (256 KB) HNMR (289 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Wang G, et al. Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C. J Med Chem. 2020 Sep 24;63(18):10380-10395. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6272 mL	8.1362 mL	16.2723 mL	40.6808 mL
	5 mM	0.3254 mL	1.6272 mL	3.2545 mL	8.1362 mL
	10 mM	0.1627 mL	0.8136 mL	1.6272 mL	4.0681 mL
	15 mM	0.1085 mL	0.5424 mL	1.0848 mL	2.7121 mL
	20 mM	0.0814 mL	0.4068 mL	0.8136 mL	2.0340 mL
	25 mM	0.0651 mL	0.3254 mL	0.6509 mL	1.6272 mL
	30 mM	0.0542 mL	0.2712 mL	0.5424 mL	1.3560 mL
	40 mM	0.0407 mL	0.2034 mL	0.4068 mL	1.0170 mL
	50 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8136 mL
	60 mM	0.0271 mL	0.1356 mL	0.2712 mL	0.6780 mL
	80 mM	0.0203 mL	0.1017 mL	0.2034 mL	0.5085 mL
	100 mM	0.0163 mL	0.0814 mL	0.1627 mL	0.4068 mL

AL-611 Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-6112481279-61-0AL611AL 611HCV ProteaseInhibitorinhibitorinhibit

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