2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Chemical Structure

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Chemical Structure

CAS No. : 211190-38-4

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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Related Antibodies

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Description

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biological active peptide. (Protease activated receptor 1 (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. This peptide is a PAR-1 selective agonist displaying a high level of specificity to PAR-1 over PAR-2. The specificity of peptide was evaluated in cell-based calcium signaling assay using HEK293 cells. PAR-1 selective agonists can be used to study PAR-1 activation in vivo. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.)

Molecular Weight

883.02

Formula

C42H63FN12O8
CAS No.
Sequence

Ala-{Phe(p-Fluoro)}-Arg-{Cha}-{Cit}-Tyr-NH2
Sequence Shortening

A-{Phe(p-Fluoro)}-R-{Cha}-{Cit}-Y-NH2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2211190-38-4Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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