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Alendronate sodium  (Synonyms: Alendronic acid monosodium salt)

Cat. No.: HY-108685
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Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis.

For research use only. We do not sell to patients.

Alendronate sodium Chemical Structure

Alendronate sodium Chemical Structure

CAS No. : 129318-43-0

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Based on 5 publication(s) in Google Scholar

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Alendronate sodium Related Antibodies

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Description

Alendronate sodium is an orally active nitrogen-containing bisphosphonate. Alendronate sodium potently inhibits bone resorption. Alendronate sodium is used for the research of postmenopausal osteoporosis[1].

Cellular Effect
Cell Line Type Value Description References
BMDM IC50
3.7 μM
Compound: Alen
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
[PMID: 31257875]
BMMC IC50
1.71 μM
Compound: Alendronate
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
Anti-osteoporosis activity in C57BL/6 mouse BMM cells assessed as inhibition of M-CSF/RANKL-induced osteoclastogenesis by measuring reduction in multinucleated TRAP+ cells incubated for 5 days with media replenishment for every 48 hrs measured by TRAP-sta
[PMID: 33485256]
RAW264.7 IC50
0.084 μM
Compound: AS
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
Antiosteoclast activity in mouse RAW264.7 cells assessed as inhibition of RANKL-induced osteoclast differentiation after 5 days by TRAP assay
10.1039/C5MD00482A
Clinical Trial
Molecular Weight

271.08

Formula

C4H12NNaO7P2
CAS No.
SMILES

O=P(O)(O)C(CCCN)(O)P(O)(O[Na])=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Alendronate sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alendronate129318-43-0Alendronic acid monosodiumOthersosteoporosisosteogenesisadipogenesisoralbisphosphonateInhibitorinhibitorinhibit

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