2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Amb123203

Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds.

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Amb123203 Chemical Structure

Amb123203 Chemical Structure

CAS No. : 956571-77-0

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Description

Amb123203 is an antiviral compound with the activity of inhibiting viral budding. Amb123203 exerts its effect by blocking the interaction between mVP40 and Nedd4 proteins. Amb123203 has a significant inhibitory effect on the budding of VP40 virus-like particles (VLPs) of Marburg (MARV) and Ebola viruses. Amb123203 can effectively target RNA viruses that rely on the PPxY L domain for efficient budding, showing broad-spectrum antiviral activity. The discovery of Amb123203 provides an important basis for the development of new broad-spectrum antiviral compounds[1].

Molecular Weight

445.58

Formula

C25H27N5OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CN1CCCC(C1)C2=NC3=C(S2)C=CC=C3)NC4=C(C)N(C5=CC=CC=C5)N=C4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (224.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2443 mL 11.2213 mL 22.4427 mL
5 mM 0.4489 mL 2.2443 mL 4.4885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2443 mL 11.2213 mL 22.4427 mL 56.1066 mL
5 mM 0.4489 mL 2.2443 mL 4.4885 mL 11.2213 mL
10 mM 0.2244 mL 1.1221 mL 2.2443 mL 5.6107 mL
15 mM 0.1496 mL 0.7481 mL 1.4962 mL 3.7404 mL
20 mM 0.1122 mL 0.5611 mL 1.1221 mL 2.8053 mL
25 mM 0.0898 mL 0.4489 mL 0.8977 mL 2.2443 mL
30 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8702 mL
40 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.4027 mL
50 mM 0.0449 mL 0.2244 mL 0.4489 mL 1.1221 mL
60 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
80 mM 0.0281 mL 0.1403 mL 0.2805 mL 0.7013 mL
100 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5611 mL
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Amb123203 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amb123203956571-77-0Amb 123203Amb-123203Endogenous MetaboliteInhibitorinhibitorinhibit

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