2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. Aminobenzenesulfonic auristatin E TFA

Aminobenzenesulfonic auristatin E TFA 

Cat. No.: HY-145989A Purity: 99.39%
COA Handling Instructions

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Aminobenzenesulfonic auristatin E TFA is a agent-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic.

For research use only. We do not sell to patients.

Aminobenzenesulfonic auristatin E TFA Chemical Structure

Aminobenzenesulfonic auristatin E TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 190 In-stock
10 mg USD 310 In-stock
25 mg USD 620 In-stock
50 mg USD 1000 In-stock
100 mg USD 1600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Aminobenzenesulfonic auristatin E TFA:

Aminobenzenesulfonic auristatin E TFA Related Antibodies

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View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Aminobenzenesulfonic auristatin E TFA is a agent-linker conjugate for ADC. Aminobenzenesulfonic auristatin E TFA has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic[1].

IC50 & Target

Auristatin

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminobenzenesulfonic auristatin E TFA Related Antibodies
Molecular Weight

867.03

Formula

C39H65F3N6O10S
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](C(N[S](=O)(C(C=C1)=CC=C1N)=O)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 330 mg/mL (380.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1534 mL 5.7668 mL 11.5336 mL
5 mM 0.2307 mL 1.1534 mL 2.3067 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1534 mL 5.7668 mL 11.5336 mL 28.8341 mL
5 mM 0.2307 mL 1.1534 mL 2.3067 mL 5.7668 mL
10 mM 0.1153 mL 0.5767 mL 1.1534 mL 2.8834 mL
15 mM 0.0769 mL 0.3845 mL 0.7689 mL 1.9223 mL
20 mM 0.0577 mL 0.2883 mL 0.5767 mL 1.4417 mL
25 mM 0.0461 mL 0.2307 mL 0.4613 mL 1.1534 mL
30 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.9611 mL
40 mM 0.0288 mL 0.1442 mL 0.2883 mL 0.7209 mL
50 mM 0.0231 mL 0.1153 mL 0.2307 mL 0.5767 mL
60 mM 0.0192 mL 0.0961 mL 0.1922 mL 0.4806 mL
80 mM 0.0144 mL 0.0721 mL 0.1442 mL 0.3604 mL
100 mM 0.0115 mL 0.0577 mL 0.1153 mL 0.2883 mL
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Aminobenzenesulfonic auristatin E TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminobenzenesulfonic auristatin EDrug-Linker Conjugates for ADCMicrotubule/TubulinAntitumorAminobenzenesulfonic auristatindrug-Linker ConjugatesInhibitorinhibitorinhibit

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