2. PROTAC
  3. PROTAC Linkers
  4. Aminooxy-PEG3-bromide hydrobromide

Aminooxy-PEG3-bromide hydrobromide 

Cat. No.: HY-140396C Purity: ≥98.0%
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Aminooxy-PEG3-bromide hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Aminooxy-PEG3-bromide hydrobromide Chemical Structure

Aminooxy-PEG3-bromide hydrobromide Chemical Structure

Size Price Stock Quantity
5 mg USD 100 In-stock
10 mg USD 166 In-stock
25 mg USD 335 In-stock
50 mg USD 540 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Aminooxy-PEG3-bromide hydrobromide:

Aminooxy-PEG3-bromide hydrobromide Related Antibodies

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Description

Aminooxy-PEG3-bromide hydrobromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminooxy-PEG3-bromide hydrobromide Related Antibodies
Molecular Weight

353.05

Formula

C8H19Br2NO4
Appearance

Oil

Color

Light yellow to yellow

SMILES

NOCCOCCOCCOCCBr.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (708.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8325 mL 14.1623 mL 28.3246 mL
5 mM 0.5665 mL 2.8325 mL 5.6649 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8325 mL 14.1623 mL 28.3246 mL 70.8115 mL
5 mM 0.5665 mL 2.8325 mL 5.6649 mL 14.1623 mL
10 mM 0.2832 mL 1.4162 mL 2.8325 mL 7.0812 mL
15 mM 0.1888 mL 0.9442 mL 1.8883 mL 4.7208 mL
20 mM 0.1416 mL 0.7081 mL 1.4162 mL 3.5406 mL
25 mM 0.1133 mL 0.5665 mL 1.1330 mL 2.8325 mL
30 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3604 mL
40 mM 0.0708 mL 0.3541 mL 0.7081 mL 1.7703 mL
50 mM 0.0566 mL 0.2832 mL 0.5665 mL 1.4162 mL
60 mM 0.0472 mL 0.2360 mL 0.4721 mL 1.1802 mL
80 mM 0.0354 mL 0.1770 mL 0.3541 mL 0.8851 mL
100 mM 0.0283 mL 0.1416 mL 0.2832 mL 0.7081 mL
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Aminooxy-PEG3-bromide hydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminooxy-PEG3-bromidePROTAC LinkersInhibitorinhibitorinhibit

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