2. PROTAC
  3. PROTAC Linkers
  4. Aminooxy-PEG3-bromide

Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Aminooxy-PEG3-bromide Chemical Structure

Aminooxy-PEG3-bromide Chemical Structure

CAS No. : 1895922-73-2

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Other Forms of Aminooxy-PEG3-bromide:

Aminooxy-PEG3-bromide Related Antibodies

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Description

Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminooxy-PEG3-bromide Related Antibodies
Molecular Weight

272.14

Formula

C8H18BrNO4
CAS No.
SMILES

NOCCOCCOCCOCCBr
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (367.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6746 mL 18.3729 mL 36.7458 mL
5 mM 0.7349 mL 3.6746 mL 7.3492 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.6746 mL 18.3729 mL 36.7458 mL 91.8645 mL
5 mM 0.7349 mL 3.6746 mL 7.3492 mL 18.3729 mL
10 mM 0.3675 mL 1.8373 mL 3.6746 mL 9.1864 mL
15 mM 0.2450 mL 1.2249 mL 2.4497 mL 6.1243 mL
20 mM 0.1837 mL 0.9186 mL 1.8373 mL 4.5932 mL
25 mM 0.1470 mL 0.7349 mL 1.4698 mL 3.6746 mL
30 mM 0.1225 mL 0.6124 mL 1.2249 mL 3.0621 mL
40 mM 0.0919 mL 0.4593 mL 0.9186 mL 2.2966 mL
50 mM 0.0735 mL 0.3675 mL 0.7349 mL 1.8373 mL
60 mM 0.0612 mL 0.3062 mL 0.6124 mL 1.5311 mL
80 mM 0.0459 mL 0.2297 mL 0.4593 mL 1.1483 mL
100 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9186 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Aminooxy-PEG3-bromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminooxy-PEG3-bromide1895922-73-2PROTAC LinkersInhibitorinhibitorinhibit

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