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  2. Isotope-Labeled Compounds Calcium Channel
  3. Amlodipine-1,1,2,2-d4 maleate

Amlodipine-1,1,2,2-d4 (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

For research use only. We do not sell to patients.

Amlodipine-1,1,2,2-d<sub>4</sub> maleate Chemical Structure

Amlodipine-1,1,2,2-d4 maleate Chemical Structure

CAS No. : 1185246-15-4

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1 mg USD 158 In-stock
5 mg USD 400 In-stock
10 mg USD 650 In-stock
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Description

Amlodipine-1,1,2,2-d4 (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

528.97

Formula

C24H25D4ClN2O9

CAS No.
Unlabeled CAS

88150-47-4

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(O)/C=C\C(O)=O.O=C(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8905 mL 9.4523 mL 18.9047 mL
5 mM 0.3781 mL 1.8905 mL 3.7809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8905 mL 9.4523 mL 18.9047 mL 47.2617 mL
5 mM 0.3781 mL 1.8905 mL 3.7809 mL 9.4523 mL
10 mM 0.1890 mL 0.9452 mL 1.8905 mL 4.7262 mL
15 mM 0.1260 mL 0.6302 mL 1.2603 mL 3.1508 mL
20 mM 0.0945 mL 0.4726 mL 0.9452 mL 2.3631 mL
25 mM 0.0756 mL 0.3781 mL 0.7562 mL 1.8905 mL
30 mM 0.0630 mL 0.3151 mL 0.6302 mL 1.5754 mL
40 mM 0.0473 mL 0.2363 mL 0.4726 mL 1.1815 mL
50 mM 0.0378 mL 0.1890 mL 0.3781 mL 0.9452 mL
60 mM 0.0315 mL 0.1575 mL 0.3151 mL 0.7877 mL
80 mM 0.0236 mL 0.1182 mL 0.2363 mL 0.5908 mL
100 mM 0.0189 mL 0.0945 mL 0.1890 mL 0.4726 mL
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Amlodipine-1,1,2,2-d4 maleate
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HY-B0317S
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