Amlodipine-1,1,2,2-d₄ maleate

Cat. No.: HY-B0317S Purity: 98.04%: FAQs
Data Sheet SDS COA Handling Instructions

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Amlodipine-1,1,2,2-d₄ (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

For research use only. We do not sell to patients.

Amlodipine-1,1,2,2-d<sub>4</sub> maleate Chemical Structure

Amlodipine-1,1,2,2-d₄ maleate Chemical Structure

CAS No. : 1185246-15-4

Size	Price	Stock	Quantity
1 mg	USD 158	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 650	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Amlodipine-1,1,2,2-d₄ maleate:

Amlodipine In-stock
(R)-Amlodipine Get quote
Amlodipine-d₄ maleate Get quote
Amlodipine-d₄ Get quote

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•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

528.97

Formula

C₂₄H₂₅D₄ClN₂O₉

CAS No.

1185246-15-4

Unlabeled CAS

88150-47-4

Appearance

Solid

Color

Light brown to brown

SMILES

O=C(O)/C=C\C(O)=O.O=C(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (189.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8905 mL	9.4523 mL	18.9047 mL
5 mM	0.3781 mL	1.8905 mL	3.7809 mL
10 mM	0.1890 mL	0.9452 mL	1.8905 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.04%

Select Batch:

Data Sheet (279 KB) SDS (949 KB)

COA (258 KB) HNMR (121 KB) RP-HPLC (383 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Kishen G. Bulsara, et al. Amlodipine.

[2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [Content Brief]

[3]. Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. [Content Brief]

[4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. [Content Brief]

[5]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8905 mL	9.4523 mL	18.9047 mL	47.2617 mL
	5 mM	0.3781 mL	1.8905 mL	3.7809 mL	9.4523 mL
	10 mM	0.1890 mL	0.9452 mL	1.8905 mL	4.7262 mL
	15 mM	0.1260 mL	0.6302 mL	1.2603 mL	3.1508 mL
	20 mM	0.0945 mL	0.4726 mL	0.9452 mL	2.3631 mL
	25 mM	0.0756 mL	0.3781 mL	0.7562 mL	1.8905 mL
	30 mM	0.0630 mL	0.3151 mL	0.6302 mL	1.5754 mL
	40 mM	0.0473 mL	0.2363 mL	0.4726 mL	1.1815 mL
	50 mM	0.0378 mL	0.1890 mL	0.3781 mL	0.9452 mL
	60 mM	0.0315 mL	0.1575 mL	0.3151 mL	0.7877 mL
	80 mM	0.0236 mL	0.1182 mL	0.2363 mL	0.5908 mL
	100 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4726 mL