2. Others
  3. Isotope-Labeled Compounds
  4. Amlodipine-d4

Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.

For research use only. We do not sell to patients.

Amlodipine-d<sub>4</sub> Chemical Structure

Amlodipine-d4 Chemical Structure

CAS No. : 1185246-14-3

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1 mg USD 253 In-stock
5 mg USD 633 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Amlodipine-d4:

Amlodipine-d4 Related Antibodies

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Description

Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Amlodipine-d4 Related Antibodies
Molecular Weight

412.90

Formula

C20H21D4ClN2O5
CAS No.
Unlabeled CAS

88150-42-9
Appearance

Solid

Color

White to yellow

SMILES

CCOC(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=C(C=CC=C2)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (75.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4219 mL 12.1095 mL 24.2189 mL
5 mM 0.4844 mL 2.4219 mL 4.8438 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.46%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4219 mL 12.1095 mL 24.2189 mL 60.5473 mL
5 mM 0.4844 mL 2.4219 mL 4.8438 mL 12.1095 mL
10 mM 0.2422 mL 1.2109 mL 2.4219 mL 6.0547 mL
15 mM 0.1615 mL 0.8073 mL 1.6146 mL 4.0365 mL
20 mM 0.1211 mL 0.6055 mL 1.2109 mL 3.0274 mL
25 mM 0.0969 mL 0.4844 mL 0.9688 mL 2.4219 mL
30 mM 0.0807 mL 0.4036 mL 0.8073 mL 2.0182 mL
40 mM 0.0605 mL 0.3027 mL 0.6055 mL 1.5137 mL
50 mM 0.0484 mL 0.2422 mL 0.4844 mL 1.2109 mL
60 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0091 mL
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Amlodipine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amlodipine-d41185246-14-3Isotope-Labeled CompoundsoraldihydropyridineantianginalhypertensionInhibitorinhibitorinhibit

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