2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. Androgen receptor antagonist 12

Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research.

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Androgen receptor antagonist 12 Chemical Structure

Androgen receptor antagonist 12 Chemical Structure

CAS No. : 6605-17-0

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Androgen receptor antagonist 12 Related Antibodies

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Description

Androgen receptor antagonist 12 (Compound EF2) is an orally active Androgen receptor (AR) antagonist (IC50: 0.30 μM). Androgen receptor antagonist 12 inhibits transcriptional activity of variant AR mutants and and the proliferation of AR-positive PCa cell lines. Androgen receptor antagonist 12 blocks AR nuclear translocation. Androgen receptor antagonist 12 inhibits tumor growth in a C4-2B xenograft mouse model. Androgen receptor antagonist 12 can be used for prostate cancer (PCa) research[1].

Molecular Weight

283.21

Formula

C12H8F3N3O2
CAS No.
SMILES

FC(C1=CC(NC2=NC=C([N+]([O-])=O)C=C2)=CC=C1)(F)F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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Androgen receptor antagonist 12 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Androgen receptor antagonist 126605-17-0Androgen receptor antagonist12Androgen receptor antagonist-12Androgen ReceptorC4-2Bprostate cancerInhibitorinhibitorinhibit

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