Angiotensin II (5-8), human

Name: Angiotensin II (5-8), human
Brand: MedChemExpress
SKU: HY-P1769
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1769 Purity: 99.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney.

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Custom Peptide Synthesis

Angiotensin II (5-8), human Chemical Structure

CAS No. : 34233-50-6

Size	Price	Stock	Quantity
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II^[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca²⁺ levels. Angiotensin II also acts at the Na⁺/H⁺ exchanger in the proximal tubules of the kidney^[2]^[3].

Molecular Weight

512.60

Formula

C₂₆H₃₆N₆O₅

CAS No.

34233-50-6

Appearance

Solid

Color

White to off-white

Sequence

Ile-His-Pro-Phe

Sequence Shortening

IHPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : ≥ 65 mg/mL (126.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9508 mL	9.7542 mL	19.5084 mL
5 mM	0.3902 mL	1.9508 mL	3.9017 mL
10 mM	0.1951 mL	0.9754 mL	1.9508 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.68%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) RP-HPLC (107 KB) MS (195 KB)

Handling Instructions (2659 KB)

References

[1]. Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27. [Content Brief]

[2]. De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. [Content Brief]

[3]. Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9508 mL	9.7542 mL	19.5084 mL	48.7710 mL
	5 mM	0.3902 mL	1.9508 mL	3.9017 mL	9.7542 mL
	10 mM	0.1951 mL	0.9754 mL	1.9508 mL	4.8771 mL
	15 mM	0.1301 mL	0.6503 mL	1.3006 mL	3.2514 mL
	20 mM	0.0975 mL	0.4877 mL	0.9754 mL	2.4385 mL
	25 mM	0.0780 mL	0.3902 mL	0.7803 mL	1.9508 mL
	30 mM	0.0650 mL	0.3251 mL	0.6503 mL	1.6257 mL
	40 mM	0.0488 mL	0.2439 mL	0.4877 mL	1.2193 mL
	50 mM	0.0390 mL	0.1951 mL	0.3902 mL	0.9754 mL
	60 mM	0.0325 mL	0.1626 mL	0.3251 mL	0.8128 mL
	80 mM	0.0244 mL	0.1219 mL	0.2439 mL	0.6096 mL
	100 mM	0.0195 mL	0.0975 mL	0.1951 mL	0.4877 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.