2. Anti-infection
  3. Bacterial
  4. ANS

ANS  (Synonyms: ANSA; 8-Anilino-1-naphthalenesulfonic acid)

Cat. No.: HY-D0896 Purity: ≥98.0%
SDS COA Handling Instructions

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8-Anilino-1-naphthalenesulfonic acid ammonium is a potent antibacterial agent and a textile dye. 8-Anilino-1-naphthalenesulfonic acid ammonium can be used as fluorescence probe. 8-Anilino-1-naphthalenesulfonic acid ammonium blocks the binding of triiodothyronine to thyroxine binding globulin in radioimmunoassay of triiodothyronine.

For research use only. We do not sell to patients.

ANS Chemical Structure

ANS Chemical Structure

CAS No. : 82-76-8

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Based on 1 publication(s) in Google Scholar

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Description

8-Anilino-1-naphthalenesulfonic acid ammonium is a potent antibacterial agent and a textile dye. 8-Anilino-1-naphthalenesulfonic acid ammonium can be used as fluorescence probe. 8-Anilino-1-naphthalenesulfonic acid ammonium blocks the binding of triiodothyronine to thyroxine binding globulin in radioimmunoassay of triiodothyronine[1][2][3].

Molecular Weight

299.34

Formula

C16H13NO3S
CAS No.
Appearance

Solid

Color

Gray to dark gray

SMILES

O=S(O)(C1=CC=CC2=CC=CC(NC3=CC=CC=C3)=C21)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (334.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3407 mL 16.7034 mL 33.4068 mL
5 mM 0.6681 mL 3.3407 mL 6.6814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (6.95 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (6.95 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (259 KB) HNMR (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3407 mL 16.7034 mL 33.4068 mL 83.5171 mL
5 mM 0.6681 mL 3.3407 mL 6.6814 mL 16.7034 mL
10 mM 0.3341 mL 1.6703 mL 3.3407 mL 8.3517 mL
15 mM 0.2227 mL 1.1136 mL 2.2271 mL 5.5678 mL
20 mM 0.1670 mL 0.8352 mL 1.6703 mL 4.1759 mL
25 mM 0.1336 mL 0.6681 mL 1.3363 mL 3.3407 mL
30 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7839 mL
40 mM 0.0835 mL 0.4176 mL 0.8352 mL 2.0879 mL
50 mM 0.0668 mL 0.3341 mL 0.6681 mL 1.6703 mL
60 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
80 mM 0.0418 mL 0.2088 mL 0.4176 mL 1.0440 mL
100 mM 0.0334 mL 0.1670 mL 0.3341 mL 0.8352 mL
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ANS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANS82-76-8ANSA 8-Anilino-1-naphthalenesulfonic acidBacterialantibacterialtextile dyefluorescence proberadioimmunoassayInhibitorinhibitorinhibit

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