2. Anti-infection
  3. Filovirus
  4. Ansuvimab

Ansuvimab  (Synonyms: Ansuvimab-zyk; mAb114)

Cat. No.: HY-P99337 Purity: 99.90%
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Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells.

For research use only. We do not sell to patients.

CAS No. : 2375952-29-5

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10 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

Ansuvimab Related Antibodies

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Description

Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus. Ansuvimab binds to the glycoprotein on Zaire ebolavirus to block its entry into host cells[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target

ZEBOV

 

In Vitro

Ansuvimab blocks binding between the Ebola virus glycoprotein (GP) and the Niemann-Pick C1 receptor by binding to the LEIKKPDGS epitope located in the receptor binding site of the GP1 subunit of GP[1].
Ansuvimab mediates antibody-dependent cellular cytotoxicity (ADCC) against GP-transfected target cells, with maximal activity at the concentration of 0.03 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ansuvimab Related Antibodies
In Vivo

Ansuvimab results in all macaques surviving after exposure to a lethal dose of Ebola virus in on day 0[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ansuvimab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Ansuvimab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ansuvimab2375952-29-5Ansuvimab-zyk mAb114mAb114mAb 114mAb-114FilovirusInhibitorinhibitorinhibit

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