2. Immunology/Inflammation
  3. PGE synthase COX
  4. Anti-inflammatory agent 78

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line.

For research use only. We do not sell to patients.

Anti-inflammatory agent 78 Chemical Structure

Anti-inflammatory agent 78 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anti-inflammatory agent 78 Related Antibodies

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line[1].

IC50 & Target

COX-1

 

COX-2

 

In Vitro

Anti-inflammatory agent 78 (compound L-37) has a high tumor cell growth inhibitory ability at 10 μM along with a significant effect on the growth of RAW 264.7 cells[1].
Anti-inflammatory agent 78 (1-10 μM, 24 h) inhibits LPS-induced PGE2 synthesis in RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 78 Related Antibodies

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Inhibited LPS-induced PGE2 synthesis in a dosedependent manner. Inhibited the PGF1 production as well as the expression of COX-1, but displayed weak inhibition activity towards the Leukotrienes (LT) and Thromboxane-B2 (TXB-2) production.
In Vivo

Anti-inflammatory agent 78 (compound L-37) (25-100 mg/kg, IP) displayed remarkable in-vivo anti-inflammatory activity via the xylene-induced mice ear edema model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (xylene-induced mice ear edema model)[1]
Dosage: 100 mg/kg
Administration: IP
Result: Exhibited a dose-dependent anti-inflammatory effect in vivo. L-37 has a slightly weaker inhibitory activity than celecoxib (HY-14398) in animal models, it also shows good activity and a nearly 78.14% inhibition rate at the dosage of 50 mg/kg.
Molecular Weight

355.77

Formula

C19H14ClNO4
SMILES

OC(C1=CC=C(Cl)C=C1N2CC3=CC=CC=C3)(C#CC(OC)=O)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anti-inflammatory agent 78 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 78PGE synthaseCOXProstaglandin E synthaseCyclooxygenasePGE2Anti-inflammatoryRAW 264.7 cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anti-inflammatory agent 78
Cat. No.:
HY-162425
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.