2. Immunology/Inflammation Anti-infection
  3. Interleukin Related Parasite
  4. Anti-Mouse IL-3 Antibody (MP2-8F8)

Anti-Mouse IL-3 Antibody (MP2-8F8) 

Cat. No.: HY-P990214 Purity: 95.00%
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Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections.

For research use only. We do not sell to patients.

Anti-Mouse IL-3 Antibody (MP2-8F8)

Anti-Mouse IL-3 Antibody (MP2-8F8) Chemical Structure

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Description

Anti-Mouse IL-3 Antibody (MP2-8F8) is an anti-mouse IL-3 IgG1 monoclonal antibody. Anti-Mouse IL-3 Antibody (MP2-8F8) relieves joint inflammation by reducing synovial leukocyte infiltration and cytokine levels. Anti-Mouse IL-3 Antibody (MP2-8F8) can reduce the accumulation of basophils. Anti-Mouse IL-3 Antibody (MP2-8F8) can be used for researches on inflammation or infection conditions such as arthritis and parasitic infections[1][2][3].

Isotype

Rat IgG1
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][2][3]

IL-3

 

In Vitro

Anti-Mouse IL-3 Antibody (MP2-8F8) (10 μg/mL, 24 h) significantly reduces the expression of ICOS-L in bone marrow-derived mast cells (BMMCs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Anti-Mouse IL-3 Antibody (MP2-8F8) (35 or 50 μg, i.p., once daily, for 7 or 15 days) can significantly improve symptoms of arthritis in male DBA/1 mice with a bovine type II collagen (CII) (HY-NP102) induced arthritis[1].
Anti-Mouse IL-3 Antibody (MP2-8F8) (2 mg, i.p., once every 3 days) reduces the accumulation of basophils in the liver after infection in Rag2-/- mice with a parasitic infection model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CII (100-200 μg) induced male DBA/1 mice[1]
Dosage: 35 μg for early blockade, 50 for late blockade
Administration: Intraperitoneal injection (i.p.), once daily, 15 days for early blockade or 7 days for late blockade
Result: Significantly reduced the score of arthritis, synovitis, and antibody titers for early blockade.
Had no significant impact on arthritis for late blockade.
Animal Model: Rag2-/- mice injected with 600 third stage infectious larvae of Nippostrongylus brasiliensis[3]
Dosage: 2 mg
Administration: Intraperitoneal injection (i.p.), once every 3 days
Result: Reduced eosinophils to 14 %.
Gene ID

16187  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-3 Antibody (MP2-8F8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-3 Antibody (MP2-8F8) Related Classifications

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Help & FAQs
  • Precautions for Product Dissolution and Storage

    Before use, briefly centrifuge the vial to collect the contents at the bottom. Then dissolve the product in RNase-free water. After reconstitution, aliquot the solution into small volumes and store at the recommended temperature. Avoid repeated freeze-thaw cycles.

Keywords:

Anti-Mouse IL-3 Antibody (MP2-8F8)Interleukin RelatedParasiteILIL-3basophilsparasiticarthritisInhibitorinhibitorinhibit

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