1. Gene
  2. Il3 - interleukin 3 Gene

Il3 - interleukin 3 Gene

Mus musculus

Also known as BPA; PSF; HCGF; Il-3; MCGF; Csfmu

Gene ID: 16187 | Gene type: protein coding

About Il3

Chromosome 11: 54,156,129-54,158,103 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 10 phenotypes.

Summary

Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 Products(1)

mRNA Protein Name
NM_010556.4 NP_034686.2 interleukin-3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine activity IDA
IDA: Inferred from direct assay
1350248 MGI
enables growth factor activity IDA
IDA: Inferred from direct assay
7957045 MGI
enables interleukin-3 receptor binding IPI
IPI: Inferred from physical interaction
19109256 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of B cell apoptotic process IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of B cell proliferation IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of JNK cascade IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of JNK cascade IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of T cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within activation of Janus kinase activity IDA
IDA: Inferred from direct assay
8378315 MGI
acts upstream of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
7519779 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
11527400 MGI
acts upstream of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within interleukin-3-mediated signaling pathway IDA
IDA: Inferred from direct assay
19109256 MGI
acts upstream of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of mast cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within monocyte differentiation IGI
IGI: Inferred from genetic interaction
19109256 MGI
acts upstream of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
10652277 MGI
acts upstream of or within myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
9202146 MGI
acts upstream of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within negative regulation of B cell apoptotic process IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: Inferred from direct assay
15680329 MGI
acts upstream of or within negative regulation of mast cell apoptotic process IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process IDA
IDA: Inferred from direct assay
10652277 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10872802 MGI
acts upstream of or within positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
7736574 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
14967141 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
1350248 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
7690439 MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of mast cell proliferation IDA
IDA: Inferred from direct assay
12714518 MGI
acts upstream of or within positive regulation of myeloid leukocyte differentiation IGI
IGI: Inferred from genetic interaction
1375116 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7519779 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: Inferred from direct assay
12944463 MGI
acts upstream of protein phosphorylation IDA
IDA: Inferred from direct assay
14967141 MGI
acts upstream of or within regulation of cell growth IGI
IGI: Inferred from genetic interaction
19109256 MGI
acts upstream of or within regulation of gene expression IDA
IDA: Inferred from direct assay
9697835 MGI
acts upstream of or within regulation of glycolytic process IGI
IGI: Inferred from genetic interaction
17437992 MGI
acts upstream of or within response to hypoxia IGI
IGI: Inferred from genetic interaction
17437992 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7690439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il3 Protein Structure

IL3

IL3: pfam02059 (34 - 137)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

interleukin-3

P-cell-stimulating factor

hematopoietic growth factor

mast cell growth factor

multipotential colony-stimulating factor

Recombinant Il3 Proteins

Cat. No. Product Name Accession Purity
HY-P7062A IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥95%
HY-P7062 IL-3 Protein, Mouse P01586 (D33-C166) ≥95%
HY-P70685 IL-3 Protein, Mouse (HEK293, His) P01586 (A27-C166) ≥95%
HY-P73207 IL-3 Protein, Mouse (HEK293) P01586 (A27-C166)/NP_034686.2 ≥95%
HY-P78313 IL-3 Protein, Mouse (HEK293, Fc) P01586 (A27-C166) ≥95%
HY-P700205AF Animal-Free IL-3 Protein, Mouse (His) P01586 (D33-C166) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Il3 NCBI NCBI:3562
Canis familiaris Il3 NCBI NCBI:481497
Macaca fascicularis Il3 NCBI NCBI:102118362
Rattus norvegicus Il3 NCBI NCBI:24495
Macaca mulatta Il3 NCBI NCBI:706946