Il3 - interleukin 3 Gene

Mus musculus

Also known as BPA; PSF; HCGF; Il-3; MCGF; Csfmu

Gene ID: 16187 | Gene type: protein coding

About Il3

Chromosome 11: 54,156,129-54,158,103 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 42 orthologues and is associated with 10 phenotypes.

Summary

Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3). [provided by Alliance of Genome Resources, Apr 2022]

Il3 Products(1)

mRNA	Protein	Name
NM_010556.4	NP_034686.2	interleukin-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1350248	MGI
enables growth factor activity	IDA IDA: Inferred from direct assay	7957045	MGI
enables interleukin-3 receptor binding	IPI IPI: Inferred from physical interaction	19109256	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IDA IDA: Inferred from direct assay	7736574	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	7736574	MGI
acts upstream of JNK cascade	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of JNK cascade	IMP IMP: Inferred from mutant phenotype	14967141	MGI
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of or within activation of Janus kinase activity	IDA IDA: Inferred from direct assay	8378315	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	1350248	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	7690439	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	7519779	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	11527400	MGI
acts upstream of hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	1375116	MGI
acts upstream of or within interleukin-3-mediated signaling pathway	IDA IDA: Inferred from direct assay	19109256	MGI
acts upstream of mast cell apoptotic process	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of mast cell proliferation	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of or within monocyte differentiation	IGI IGI: Inferred from genetic interaction	19109256	MGI
acts upstream of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	10652277	MGI
acts upstream of or within myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	9202146	MGI
acts upstream of myeloid leukocyte differentiation	IGI IGI: Inferred from genetic interaction	1375116	MGI
acts upstream of or within negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	7736574	MGI
acts upstream of or within negative regulation of autophagy	IDA IDA: Inferred from direct assay	15680329	MGI
acts upstream of or within negative regulation of mast cell apoptotic process	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	10652277	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10872802	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	7736574	MGI
acts upstream of or within positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of or within positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	14967141	MGI
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1350248	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	7690439	MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	1375116	MGI
acts upstream of or within positive regulation of mast cell proliferation	IDA IDA: Inferred from direct assay	12714518	MGI
acts upstream of or within positive regulation of myeloid leukocyte differentiation	IGI IGI: Inferred from genetic interaction	1375116	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7519779	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	12944463	MGI
acts upstream of protein phosphorylation	IDA IDA: Inferred from direct assay	14967141	MGI
acts upstream of or within regulation of cell growth	IGI IGI: Inferred from genetic interaction	19109256	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	9697835	MGI
acts upstream of or within regulation of glycolytic process	IGI IGI: Inferred from genetic interaction	17437992	MGI
acts upstream of or within response to hypoxia	IGI IGI: Inferred from genetic interaction	17437992	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7690439	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il3 Protein Structure

IL3

0
100
166 a.a.

Protein Preferred Names

Protein Names

interleukin-3

P-cell-stimulating factor	hematopoietic growth factor
mast cell growth factor	multipotential colony-stimulating factor

Recombinant Il3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7062A	IL-3 Protein, Mouse (His)	P01586 (D33-C166)	≥95%
HY-P7062	IL-3 Protein, Mouse	P01586 (D33-C166)	≥95%
HY-P70685	IL-3 Protein, Mouse (HEK293, His)	P01586 (A27-C166)	≥95%
HY-P73207	IL-3 Protein, Mouse (HEK293)	P01586 (A27-C166)/NP_034686.2	≥95%
HY-P78313	IL-3 Protein, Mouse (HEK293, Fc)	P01586 (A27-C166)	≥95%
HY-P700205AF	Animal-Free IL-3 Protein, Mouse (His)	P01586 (D33-C166)	≥95%

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1402	Hydrocortisone hemisuccinate	Inhibitor	99.83%	Unkown
HY-B1402B	Hydrocortisone hemisuccinate sodium	Inhibitor	99.66%	Unkown
HY-B1402A	Hydrocortisone hemisuccinate hydrate	Inhibitor	/	Unkown
HY-B1402R	Hydrocortisone hemisuccinate (Standard)		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99536	Tagraxofusp	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-113271	5-Androstenetriol	Activator	/	Phase 4

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99395	Talacotuzumab	Inhibitor	98.82%	Phase 3
HY-P99234	Pivekimab	Inhibitor	97.19%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06764	IL3RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-112378	D-65476	Inhibitor	/	Unkown
HY-121874	EP009	Inhibitor	/	Unkown
HY-126619	Aspochalasin D		/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-168444	CDK4/6-IN-23	Inhibitor	/	Unkown
HY-P1111	Lyn peptide inhibitor	Inhibitor	/	Unkown
HY-P1111A	Lyn peptide inhibitor TFA	Inhibitor	/	Unkown
HY-RS06751	IL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06752	Il3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06753	Il3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14271	Acreozast		/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990094	Trabikibart		99.17%	Unkown
HY-P990905	Bexatamig	Inhibitor	/	Unkown
HY-P990214	Anti-Mouse IL-3 Antibody (MP2-8F8)	Inhibitor	95.00%	Unkown
HY-P990451	Anti-IL-3Ra/CD123 Antibody (SNG-CD123A)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il3	NCBI	NCBI:3562
Canis familiaris	Il3	NCBI	NCBI:481497
Macaca fascicularis	Il3	NCBI	NCBI:102118362
Rattus norvegicus	Il3	NCBI	NCBI:24495
Macaca mulatta	Il3	NCBI	NCBI:706946

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