Antibacterial agent 195

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Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MIC_S.aureus=0.021 mg/mL; MIC_P.acnes=0.030 mg/mL), Gram-negative bacterium (MIC_E.coli=0.092 mg/mL; MIC_C.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL).

For research use only. We do not sell to patients.

Antibacterial agent 195 Chemical Structure

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Description	Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MIC_S.aureus=0.021 mg/mL; MIC_P.acnes=0.030 mg/mL), Gram-negative bacterium (MIC_E.coli=0.092 mg/mL; MIC_C.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL)^[1].
Molecular Weight	581.67
Formula	C₃₃H₃₈F₃N₃O₃
SMILES	O=C(C1=CC2=C(C=C(CC3=CC=C(C(F)(F)F)C=C3)C=C2)N1)N4[C@@](CCCC(OC)=O)([H])[C@]5([H])[C@](N6CCC5)([H])[C@](CCC6)([H])C4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Yufang Li, et al. Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics. Bioorg Med Chem Lett. 2024 Feb 21:102:129671. [Content Brief]