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Anticancer agent 46 (compound 2) is a potent anticancer agent. Anticancer agent 46 shows antiproliferative activity with an IC50 of 0.986 µM for MGC803 cells. Anticancer agent 46 has the potential for the research of gastric cancer.

For research use only. We do not sell to patients.

Anticancer agent 46 Chemical Structure

Anticancer agent 46 Chemical Structure

CAS No. : 2426686-17-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Anticancer agent 46 (compound 2) is a potent anticancer agent. Anticancer agent 46 shows antiproliferative activity with an IC50 of 0.986 µM for MGC803 cells. Anticancer agent 46 has the potential for the research of gastric cancer[1].

Cellular Effect
Cell Line Type Value Description References
GES1 IC50
27.93 μM
Compound: 5n
Cytotoxicity against human GES-1 cells after 72 hrs by MTT assay
Cytotoxicity against human GES-1 cells after 72 hrs by MTT assay
[PMID: 30108734]
MCF7 IC50
9.99 μM
Compound: 5n
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30108734]
MGC-803 IC50
> 64 μM
Compound: 5n
Antiproliferative activity against human MGC803 cells after 24 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 24 hrs by MTT assay
[PMID: 30108734]
MGC-803 IC50
0.93 μM
Compound: 5n
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
[PMID: 30108734]
MGC-803 IC50
0.986 μM
Compound: 2
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell growth incubated for 72 hrs by MTT assay
[PMID: 32438199]
MGC-803 IC50
9.22 μM
Compound: 5n
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
[PMID: 30108734]
SMMC-7721 IC50
19.18 μM
Compound: 5n
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 30108734]
Molecular Weight

319.81

Formula

C15H14ClN3OS

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C/C(C1=CC(Cl)=CC=C1O)=N\NC(NC2=CC=CC=C2)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (390.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1269 mL 15.6343 mL 31.2686 mL
5 mM 0.6254 mL 3.1269 mL 6.2537 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1269 mL 15.6343 mL 31.2686 mL 78.1714 mL
5 mM 0.6254 mL 3.1269 mL 6.2537 mL 15.6343 mL
10 mM 0.3127 mL 1.5634 mL 3.1269 mL 7.8171 mL
15 mM 0.2085 mL 1.0423 mL 2.0846 mL 5.2114 mL
20 mM 0.1563 mL 0.7817 mL 1.5634 mL 3.9086 mL
25 mM 0.1251 mL 0.6254 mL 1.2507 mL 3.1269 mL
30 mM 0.1042 mL 0.5211 mL 1.0423 mL 2.6057 mL
40 mM 0.0782 mL 0.3909 mL 0.7817 mL 1.9543 mL
50 mM 0.0625 mL 0.3127 mL 0.6254 mL 1.5634 mL
60 mM 0.0521 mL 0.2606 mL 0.5211 mL 1.3029 mL
80 mM 0.0391 mL 0.1954 mL 0.3909 mL 0.9771 mL
100 mM 0.0313 mL 0.1563 mL 0.3127 mL 0.7817 mL
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Anticancer agent 46 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Anticancer agent 46
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