2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Apoptosis Bcl-2 Family Caspase Reactive Oxygen Species
  4. Anticancer agent 56

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9.

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Anticancer agent 56 Chemical Structure

Anticancer agent 56 Chemical Structure

CAS No. : 2241915-59-1

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Anticancer agent 56 Related Antibodies

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Description

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC50<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9[1].

IC50 & Target

IC50: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3[1]
Molecular Weight

383.83

Formula

C20H18ClN3O3
CAS No.
SMILES

COC1=C(C=C(C=C1)/C=C/C(C2=C(N(N=N2)C3=CC=C(C=C3)Cl)C)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 56 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 562241915-59-1Anticancer agent56Anticancer agent-56ApoptosisBcl-2 FamilyCaspaseReactive Oxygen SpeciesAnticancerMitochondrial apoptotic pathwayRPMI-8226SRK-562M14MCF7HCT116PC3Inhibitorinhibitorinhibit

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