Anticonvulsant agent 2

Name: Anticonvulsant agent 2
Brand: MedChemExpress
SKU: HY-154436
Rating: 4.5 (1 reviews)

Cat. No.: HY-154436: FAQs
Data Sheet Handling Instructions

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Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity.

For research use only. We do not sell to patients.

Anticonvulsant agent 2 Chemical Structure

CAS No. : 75220-84-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 85	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 145	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 485	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity^[1].

In Vivo

Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) decreases locomotor activity with an inhibition rate of 21.01% in rat^[1].
Anticonvulsant agent 2 (50 mg/kg; p.o.) shows antiepileptic activity with an inhibition rate of 24.45% in rat^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	180-250g, male Wistar rats^[1]
Dosage:	50 mg/kg
Administration:	P.o.
Result:	Showed antiepileptic activity with the inhibition rate of 24.45%.

Molecular Weight

332.83

Formula

C₂₁H₁₇ClN₂

CAS No.

75220-84-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

ClC1=CC=C(C2=NC3=CC=CC=C3NC(C4=CC=CC=C4)C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (375.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0045 mL	15.0227 mL	30.0454 mL
5 mM	0.6009 mL	3.0045 mL	6.0091 mL
10 mM	0.3005 mL	1.5023 mL	3.0045 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0045 mL	15.0227 mL	30.0454 mL	75.1134 mL
	5 mM	0.6009 mL	3.0045 mL	6.0091 mL	15.0227 mL
	10 mM	0.3005 mL	1.5023 mL	3.0045 mL	7.5113 mL
	15 mM	0.2003 mL	1.0015 mL	2.0030 mL	5.0076 mL
	20 mM	0.1502 mL	0.7511 mL	1.5023 mL	3.7557 mL
	25 mM	0.1202 mL	0.6009 mL	1.2018 mL	3.0045 mL
	30 mM	0.1002 mL	0.5008 mL	1.0015 mL	2.5038 mL
	40 mM	0.0751 mL	0.3756 mL	0.7511 mL	1.8778 mL
	50 mM	0.0601 mL	0.3005 mL	0.6009 mL	1.5023 mL
	60 mM	0.0501 mL	0.2504 mL	0.5008 mL	1.2519 mL
	80 mM	0.0376 mL	0.1878 mL	0.3756 mL	0.9389 mL
	100 mM	0.0300 mL	0.1502 mL	0.3005 mL	0.7511 mL