Antipain dihydrochloride

Name: Antipain dihydrochloride
Brand: MedChemExpress
SKU: HY-127034
Rating: 4.5 (1 reviews)

Cat. No.: HY-127034 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.

For research use only. We do not sell to patients.

Antipain dihydrochloride Chemical Structure

CAS No. : 37682-72-7

Size	Price	Stock	Quantity
1 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Antipain dihydrochloride:

Antipain Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls^[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

677.62

Formula

C₂₇H₄₆Cl₂N₁₀O₆

CAS No.

37682-72-7

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](NC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (73.79 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4758 mL	7.3788 mL	14.7575 mL
5 mM	0.2952 mL	1.4758 mL	2.9515 mL
10 mM	0.1476 mL	0.7379 mL	1.4758 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (280 KB) SDS (252 KB)

COA (260 KB)

Handling Instructions (2659 KB)

References

[1]. DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53. [Content Brief]

[2]. Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6. [Content Brief]

[3]. Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76. [Content Brief]

[4]. Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626. [Content Brief]

[5]. Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4758 mL	7.3788 mL	14.7575 mL	36.8938 mL
	5 mM	0.2952 mL	1.4758 mL	2.9515 mL	7.3788 mL
	10 mM	0.1476 mL	0.7379 mL	1.4758 mL	3.6894 mL
	15 mM	0.0984 mL	0.4919 mL	0.9838 mL	2.4596 mL
	20 mM	0.0738 mL	0.3689 mL	0.7379 mL	1.8447 mL
	25 mM	0.0590 mL	0.2952 mL	0.5903 mL	1.4758 mL
	30 mM	0.0492 mL	0.2460 mL	0.4919 mL	1.2298 mL
	40 mM	0.0369 mL	0.1845 mL	0.3689 mL	0.9223 mL
	50 mM	0.0295 mL	0.1476 mL	0.2952 mL	0.7379 mL
	60 mM	0.0246 mL	0.1230 mL	0.2460 mL	0.6149 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.