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  4. Antiparasitic agent-6

Antiparasitic agent-6 (compound 5b) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 3.89 μM. Antiparasitic agent-6 also has certain cytotoxicity against HepG2 (CC50 = 13.64 μM).

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Antiparasitic agent-6 Chemical Structure

Antiparasitic agent-6 Chemical Structure

CAS No. : 2253996-73-3

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Antiparasitic agent-6 Related Antibodies

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Description

Antiparasitic agent-6 (compound 5b) has selectively antiparasitic activity against Leishmania infantum (L. infantum) with an IC50 value of 3.89 μM. Antiparasitic agent-6 also has certain cytotoxicity against HepG2 (CC50 = 13.64 μM)[1].

IC50 & Target

IC50: 3.89 μM (L. infantum)[1]
Cellular Effect
Cell Line Type Value Description References
HepG2 CC50
13.64 μM
Compound: 5b
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay
[PMID: 32590115]
HFF-1 CC50
> 64 μM
Compound: 5b
Cytotoxicity against human HFF-1 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay
Cytotoxicity against human HFF-1 cells assessed as reduction in cell viability incubated for 120 hrs by MTS assay
[PMID: 32590115]
Molecular Weight

333.34

Formula

C19H15N3O3
CAS No.
SMILES

N#CC1=CC=C(C(O)C(C2=NC(C3=CC=C(OC)C=C3)=NO2)=C)C=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Antiparasitic agent-6 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiparasitic agent-62253996-73-3Antiparasitic agent6Antiparasitic agent 6ParasiteL. InfantumAntiparasiticIntracellular amastigotesHepG2Inhibitorinhibitorinhibit

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