Antiproliferative agent-15

Name: Antiproliferative agent-15
Brand: MedChemExpress
SKU: HY-W278944
Rating: 4.5 (1 reviews)

Cat. No.: HY-W278944 Purity: 99.18%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines.

For research use only. We do not sell to patients.

Antiproliferative agent-15 Chemical Structure

CAS No. : 19819-18-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	> 100 μM Compound: 6a	Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay Antiproliferative activity against human A2780 cells after 72 hrs by MTT assay	[PMID: 28759878]
CHO	IC₅₀	> 100 μM Compound: 6a	Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay Cytotoxicity against CHO cells assessed as reduction in cell survival after 72 hrs by MTT assay	[PMID: 28759878]
HCT-116	IC₅₀	> 10 μM Compound: 4e	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability measured after 24 to 48 hrs by MTT assay	[PMID: 32153186]
HCT-116	IC₅₀	8.3 μM Compound: 6a	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 28759878]
HCT-15	IC₅₀	4.8 μM Compound: 6a	Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT15 cells after 72 hrs by MTT assay	[PMID: 28759878]
LN-229	IC₅₀	18.3 μM Compound: 6a	Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay Antiproliferative activity against human LN229 cells after 72 hrs by MTT assay	[PMID: 28759878]
MCF7	IC₅₀	> 30 μM Compound: 6c	Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay	[PMID: 29172540]
MDA-MB-231	IC₅₀	> 30 μM Compound: 6c	Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 29172540]

In Vitro

Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

282.36

Formula

C₁₆H₁₄N₂OS

CAS No.

19819-18-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C(CCCC2)=C2S3)=C3N=C(C4=CC=CC=C4)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 1.67 mg/mL (5.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5416 mL	17.7079 mL	35.4158 mL
5 mM	0.7083 mL	3.5416 mL	7.0832 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Purity & Documentation

Purity: 99.18%

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Data Sheet (273 KB) SDS (393 KB)

COA (253 KB) HNMR (259 KB) RP-HPLC (229 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Haneen Amawi, et al. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. Eur J Med Chem. 2017 Sep 29;138:1053-1065. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5416 mL	17.7079 mL	35.4158 mL	88.5395 mL
DMSO	5 mM	0.7083 mL	3.5416 mL	7.0832 mL	17.7079 mL