Antitumor agent-63

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Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak direct topoisomerase I (Topo I) inhibition.

For research use only. We do not sell to patients.

Antitumor agent-63 Chemical Structure

CAS No. : 1627600-90-1

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Topoisomerase Topo I Topo II

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Purity & Documentation
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Description

IC₅₀ & Target

Top1

In Vitro

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC₅₀ values of 1.2, 0.8, 30.5 and >100 µM against HepG2, HCT-116, SW1990 and HEK-293, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

846.79

Formula

C₃₈H₄₆N₄O₁₈

CAS No.

1627600-90-1

SMILES

O[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)OC(N)=O)[C@H]1O[C@@H]([C@H]([C@@H]([C@@H](O2)CO)O)O)[C@H]2OCCOCCNC(O[C@]3(C4=C(COC3=O)C(N5C(C6=NC7=CC=CC=C7C=C6C5)=C4)=O)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509. [Content Brief]

Cell Assay	MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Li M, et al. Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation. Eur J Med Chem. 2020 Sep 15;202:112509. [Content Brief]