2. Others Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds Androgen Receptor
  4. Apalutamide-13C,d3

Apalutamide-13C,d3  (Synonyms: ARN-509-13C,d3)

Cat. No.: HY-16060S2 Purity: 99.90%
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Apalutamide-13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

For research use only. We do not sell to patients.

Apalutamide-<sup>13</sup>C,d<sub>3</sub> Chemical Structure

Apalutamide-13C,d3 Chemical Structure

Size Price Stock Quantity
500 μg USD 410 In-stock
1 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Apalutamide-13C,d3:

Apalutamide-13C,d3 Related Antibodies

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Description

Apalutamide-13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[38].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apalutamide-13C,d3 Related Antibodies
Molecular Weight

481.45

Formula

C2013CH12D3F4N5O2S
Unlabeled CAS

956104-40-8
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[13C]([2H])([2H])[2H])C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.85 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0771 mL 10.3853 mL 20.7706 mL
5 mM 0.4154 mL 2.0771 mL 4.1541 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0771 mL 10.3853 mL 20.7706 mL 51.9265 mL
5 mM 0.4154 mL 2.0771 mL 4.1541 mL 10.3853 mL
10 mM 0.2077 mL 1.0385 mL 2.0771 mL 5.1926 mL
15 mM 0.1385 mL 0.6924 mL 1.3847 mL 3.4618 mL
20 mM 0.1039 mL 0.5193 mL 1.0385 mL 2.5963 mL
25 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0771 mL
30 mM 0.0692 mL 0.3462 mL 0.6924 mL 1.7309 mL
40 mM 0.0519 mL 0.2596 mL 0.5193 mL 1.2982 mL
50 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0385 mL
60 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8654 mL
80 mM 0.0260 mL 0.1298 mL 0.2596 mL 0.6491 mL
100 mM 0.0208 mL 0.1039 mL 0.2077 mL 0.5193 mL
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Apalutamide-13C,d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apalutamide-13C,d3ARN-509-13C,d3Isotope-Labeled CompoundsAndrogen ReceptorInhibitorinhibitorinhibit

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