2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Apoptosis
  3. EGFR Akt p38 MAPK ERK Apoptosis
  4. Apoptosis inducer 35

Apoptosis inducer 35 (Compound 6) is a multi-targeted inhibitor, that reduces the expressions of EGFR, AKT, ERK and P38-MAPKα. Apoptosis inducer 35 inhibits the proliferation of cancer cell A549 and Jurkat, arrests the cell cycle at S phase, and induces apoptosis.

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Apoptosis inducer 35 Chemical Structure

Apoptosis inducer 35 Chemical Structure

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Apoptosis inducer 35 Related Antibodies

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Akt Akt1 Akt2 Akt3

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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ERK ERK1 ERK2 ERK5 ERK8

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Description

Apoptosis inducer 35 (Compound 6) is a multi-targeted inhibitor, that reduces the expressions of EGFR, AKT, ERK and P38-MAPKα. Apoptosis inducer 35 inhibits the proliferation of cancer cell A549 and Jurkat, arrests the cell cycle at S phase, and induces apoptosis[1].

Molecular Weight

541.05

Formula

C23H21ClN8O2S2
SMILES

CCOC(CSC1=NN=C(CSC2=NN=C(C3=CC4=C(C=CC=C4)N3)N2N)N1C5=CC=C(Cl)C=C5)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
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Apoptosis inducer 35 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 35Apoptosis inducer35Apoptosis inducer-35EGFRAktp38 MAPKERKApoptosisEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesA549JurkatWI-38Inhibitorinhibitorinhibit

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