Apoptosis inducer 4

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Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities.

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Apoptosis inducer 4 Chemical Structure

CAS No. : 2408050-83-7

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Description

Apoptosis inducer 4 (Compound 12b) is an apoptosis inducer with anticancer activities^[1].

In Vitro

Apoptosis inducer 4 (Compound 12b) (0-50 µM, 72 h) shows antiproliferative activities against cancer cells without obvious cytotoxicity against normal cells^[1].
Apoptosis inducer 4 (0-2 µM, 48 h) causes cell cycle arrest at S phase in K562 cells and G1 phase in HepG2 cells^[1].
Apoptosis inducer 4 (0-4 µM, 24 and 48 h) induces pyknosis in K562 cells, and induces mitochondrial membrane potentials decline^[1].
Apoptosis inducer 4 (0-2 µM, 72 h) induces apoptosis in K562 and HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC
Concentration:	0-50 µM
Incubation Time:	72 h
Result:	Showed antiproliferative activities with IC₅₀ values of 2.57 ± 0.12, 16.15 ± 1.02, 5.81 ± 1.17, 12.94 ± 0.88, 0.95 ± 0.06, 17.59 ± 0.93 and >50 µM against HepG2, MCF-7, HCT-116, B16, K562, L-02 and PBMC cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:	K562 and HepG2 cells
Concentration:	K562 and HepG2 cells
Incubation Time:	48 h
Result:	Arrested K562 cell cycle at S phase and HepG2 cell at G1 phase.

Apoptosis Analysis^[1]

Cell Line:	K562 and HepG2 cells
Concentration:	K562 and HepG2 cells
Incubation Time:	72 h
Result:	Apoptotic ratios of K562 and HepG2 cells obviously increased in a concentration-dependent manner.

Molecular Weight

815.02

Formula

C₄₁H₅₀O₁₁S₃

CAS No.

2408050-83-7

SMILES

O[C@]12[C@]34[C@](CC[C@@H](C(C4=O)=C)[C@H]3OC(CCC(OCCCCCCOC5=CC=C(C(SS6)=CC6=S)C=C5)=O)=O)([H])[C@@]7(CO2)[C@](C(C)(CC[C@@H]7OC(C)=O)C)([H])[C@@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li H, et al. Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways. Eur J Med Chem. 2020 Feb 1;187:111978. [Content Brief]