2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Aptiganel hydrochloride

Aptiganel hydrochloride  (Synonyms: CNS 1102)

Cat. No.: HY-110097 Purity: 99.80%
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Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.

For research use only. We do not sell to patients.

Aptiganel hydrochloride Chemical Structure

Aptiganel hydrochloride Chemical Structure

CAS No. : 137160-11-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Aptiganel hydrochloride:

Aptiganel hydrochloride Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.

IC50 & Target

NMDA Receptor

 

Molecular Weight

339.86

Formula

C20H22ClN3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N=C(N(C)C1=CC=CC(CC)=C1)NC2=CC=CC3=C2C=CC=C3.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (294.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9424 mL 14.7119 mL 29.4239 mL
5 mM 0.5885 mL 2.9424 mL 5.8848 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9424 mL 14.7119 mL 29.4239 mL 73.5597 mL
5 mM 0.5885 mL 2.9424 mL 5.8848 mL 14.7119 mL
10 mM 0.2942 mL 1.4712 mL 2.9424 mL 7.3560 mL
15 mM 0.1962 mL 0.9808 mL 1.9616 mL 4.9040 mL
20 mM 0.1471 mL 0.7356 mL 1.4712 mL 3.6780 mL
25 mM 0.1177 mL 0.5885 mL 1.1770 mL 2.9424 mL
30 mM 0.0981 mL 0.4904 mL 0.9808 mL 2.4520 mL
40 mM 0.0736 mL 0.3678 mL 0.7356 mL 1.8390 mL
50 mM 0.0588 mL 0.2942 mL 0.5885 mL 1.4712 mL
60 mM 0.0490 mL 0.2452 mL 0.4904 mL 1.2260 mL
80 mM 0.0368 mL 0.1839 mL 0.3678 mL 0.9195 mL
100 mM 0.0294 mL 0.1471 mL 0.2942 mL 0.7356 mL
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Aptiganel hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aptiganel137160-11-3CNS 1102CNS1102CNS-1102iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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