Arachidonoyl Serinol

Name: Arachidonoyl Serinol
Brand: MedChemExpress
SKU: HY-121476
Rating: 4.5 (1 reviews)

Cat. No.: HY-121476 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [³H]2-oleoylglycerol and [³H]anandamide with IC₅₀s of ～70 μM.

For research use only. We do not sell to patients.

Arachidonoyl Serinol Chemical Structure

CAS No. : 183718-70-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

monoacylglycerol lipase (MAGL)^[1]

In Vitro

Arachidonoyl Serinol (0.2-100 μM) inhibits the hydrolysis of [³H]2-oleoylglycerol and [³H]anandamide with IC₅₀s of ～70 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.56

Formula

C₂₃H₃₉NO₃

CAS No.

183718-70-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)NC(CO)CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (264.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6486 mL	13.2429 mL	26.4859 mL
5 mM	0.5297 mL	2.6486 mL	5.2972 mL
10 mM	0.2649 mL	1.3243 mL	2.6486 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (238 KB) HNMR (125 KB)

Handling Instructions (2659 KB)

References

[1]. Khanolkar AD, et, al. Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J Med Chem. 1996 Oct 25;39(22):4515-9. [Content Brief]

[2]. Fowler CJ, et, al. Cyclooxygenation of the arachidonoyl side chain of 1-arachidonoylglycerol and related compounds block their ability to prevent anandamide and 2-oleoylglycerol metabolism by rat brain in vitro. Biochem Pharmacol. 2005 Apr 15;69(8):1241-5. [Content Brief]

[3]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6486 mL	13.2429 mL	26.4859 mL	66.2146 mL
	5 mM	0.5297 mL	2.6486 mL	5.2972 mL	13.2429 mL
	10 mM	0.2649 mL	1.3243 mL	2.6486 mL	6.6215 mL
	15 mM	0.1766 mL	0.8829 mL	1.7657 mL	4.4143 mL
	20 mM	0.1324 mL	0.6621 mL	1.3243 mL	3.3107 mL
	25 mM	0.1059 mL	0.5297 mL	1.0594 mL	2.6486 mL
	30 mM	0.0883 mL	0.4414 mL	0.8829 mL	2.2072 mL
	40 mM	0.0662 mL	0.3311 mL	0.6621 mL	1.6554 mL
	50 mM	0.0530 mL	0.2649 mL	0.5297 mL	1.3243 mL
	60 mM	0.0441 mL	0.2207 mL	0.4414 mL	1.1036 mL
	80 mM	0.0331 mL	0.1655 mL	0.3311 mL	0.8277 mL
	100 mM	0.0265 mL	0.1324 mL	0.2649 mL	0.6621 mL