PI3Kγ inhibitor AZ2

Name: PI3Kγ inhibitor AZ2
Brand: MedChemExpress
SKU: HY-111570
Rating: 4.5 (1 reviews)

Cat. No.: HY-111570 Purity: 99.25%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC₅₀ value for PI3Kγ is 9.3). PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases.

For research use only. We do not sell to patients.

PI3Kγ inhibitor AZ2 Chemical Structure

CAS No. : 2231760-33-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 330	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE PI3Kγ inhibitor AZ2

•Nat Cancer. 2024 May 30. [Abstract]

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•Related Screening Libraries:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC₅₀ value for PI3Kγ is 9.3). PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases^[1].

IC₅₀ & Target^[1]

PI3Kγ

9.3 (pIC₅₀)

PI3Kδ

6.6 (pIC₅₀)

PI3Kα

5.1 (pIC₅₀)

PI3Kβ

4.5 (pIC₅₀)

In Vitro

PI3Kγ inhibitor AZ2 (0.1~100 nM; 1 hour; SKOV-3 cells) excellent selectivity for PI3Kγ is further confirmed with a constitutively activated PI3K/Akt pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

369.48

Formula

C₂₀H₂₃N₃O₂S

CAS No.

2231760-33-9

Appearance

Solid

Color

White to off-white

SMILES

CC1=C2C(CN([C@H](C3CC3)C)C2=O)=CC(C4=C(C)N=C(NC(C)=O)S4)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (135.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7065 mL	13.5325 mL	27.0651 mL
5 mM	0.5413 mL	2.7065 mL	5.4130 mL
10 mM	0.2707 mL	1.3533 mL	2.7065 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.77 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) HNMR (268 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15(4):348-357. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7065 mL	13.5325 mL	27.0651 mL	67.6627 mL
	5 mM	0.5413 mL	2.7065 mL	5.4130 mL	13.5325 mL
	10 mM	0.2707 mL	1.3533 mL	2.7065 mL	6.7663 mL
	15 mM	0.1804 mL	0.9022 mL	1.8043 mL	4.5108 mL
	20 mM	0.1353 mL	0.6766 mL	1.3533 mL	3.3831 mL
	25 mM	0.1083 mL	0.5413 mL	1.0826 mL	2.7065 mL
	30 mM	0.0902 mL	0.4511 mL	0.9022 mL	2.2554 mL
	40 mM	0.0677 mL	0.3383 mL	0.6766 mL	1.6916 mL
	50 mM	0.0541 mL	0.2707 mL	0.5413 mL	1.3533 mL
	60 mM	0.0451 mL	0.2255 mL	0.4511 mL	1.1277 mL
	80 mM	0.0338 mL	0.1692 mL	0.3383 mL	0.8458 mL
	100 mM	0.0271 mL	0.1353 mL	0.2707 mL	0.6766 mL