2. Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease JAK/STAT Signaling Stem Cell/Wnt
  3. Apoptosis Bcl-2 Family Caspase COX MMP STAT
  4. Artobiloxanthone

Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9.

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Artobiloxanthone Chemical Structure

Artobiloxanthone Chemical Structure

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Artobiloxanthone Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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COX COX-1 COX-2 COX-3

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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STAT3 STAT5 STAT6 STAT1

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Description

Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). Artobiloxanthone inhibits Akt/mTOR pathway and STAT3 pathway, inhibits proliferation of SAS and T.Tn (with IC50 of 11 and 22 μM), and inhibits the cancer cell migration. Artobiloxanthone arrests cell cycle at S phase, and induces apoptosis in OSCC cells through activation of caspase 3/9[1].

Molecular Weight

434.44

Formula

C25H22O7
SMILES

C=C(C1CC2=C(C3=C(C=C(C(O)=C31)O)O)OC4=C5C=CC(C)(OC5=CC(O)=C4C2=O)C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Artobiloxanthone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ArtobiloxanthoneApoptosisBcl-2 FamilyCaspaseCOXMMPSTATCyclooxygenaseMatrix metalloproteinasesOSCCoral squamous cell carcinomaArtocarpus altilisSAST.TnHaCaTInhibitorinhibitorinhibit

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