2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Anti-infection
  3. STAT Apoptosis Antibiotic
  4. Ascochlorin

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity.

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Ascochlorin Chemical Structure

Ascochlorin Chemical Structure

CAS No. : 26166-39-2

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Ascochlorin Related Antibodies

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Description

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[1][2][3].

IC50 & Target[3]

STAT3

 

Apoptosis

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.9 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 34781681]
HepG2 IC50
0.9 μM
Compound: 7
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
[PMID: 34781681]
MDA-MB-231 IC50
2.2 μM
Compound: 12
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
[PMID: 34516133]
MDA-MB-468 IC50
1.1 μM
Compound: 12
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 24 hrs by CellTiter-Glo luminescent assay
[PMID: 34516133]
In Vitro

Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner[3].
Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells[3].
Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ascochlorin Related Antibodies

Cell Viability Assay[3]

Cell Line: HepG2, HCCLM3, Huh7 cells
Concentration: 10, 25, 50 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibit the viability of three different HCC cell lines tested (HepG2, HCCLM3 and Huh7) in a time and dose dependent manner.

Western Blot Analysis[3]

Cell Line: HepG2 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited expression of the cell cycle regulator protein cyclin D1, the anti-apoptotic proteins Bcl-2, Mcl-1, survivin and XIAP, and the invasive gene product MMP-9.
In Vivo

Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31) inhibits tumor growth in an orthotopic HCC mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight week-old athymic balb/c nude female mice (HCCLM3-Luc2 tumors)[3]
Dosage: 2.5 mg/kg, 5 mg/kg
Administration: I.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31
Result: Induced significant inhibition of tumor growth.
Molecular Weight

404.93

Formula

C23H29ClO4
CAS No.
SMILES

O=CC1=C(O)C(C/C=C(C)/C=C/[C@]2(C)[C@@H](C)C(CC[C@H]2C)=O)=C(O)C(Cl)=C1C
Structure Classification
Initial Source

Ascochyta viciae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ascochlorin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascochlorin26166-39-2Ilicicolin DSTATApoptosisAntibioticCOX-2HepG2HCCcyclinviabilityathymicbalb/cnudemiceanti-inflammatorytumorInhibitorinhibitorinhibit

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