2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis Anti-infection
  3. STAT Apoptosis Antibiotic
  4. Ascochlorin

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity.

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Ascochlorin Chemical Structure

Ascochlorin Chemical Structure

CAS No. : 26166-39-2

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Ascochlorin Related Antibodies

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Description

Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[1][2][3].

IC50 & Target[3]

STAT3

 

Apoptosis

 

In Vitro

Ascochlorin (Ilicicolin D) (10-50 μM; 24-72 hours) inhibits the viability of HepG2, HCCLM3 and Huh7 cells in a time and dose dependent manner[3].
Ascochlorin (50 μM; 48 hours) induces apoptosis in HCC cells[3].
Ascochlorin (1-50 μM) significantly suppresses the production of nitric oxide (NO) and prostaglandin E2 (PGE2) and decreases the gene expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Ascochlorin inhibits the mRNA expression and the protein secretion of interleukin (IL)-1β and IL-6 but not tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophage cells. Ascochlorin suppresses nuclear translocation and DNA binding affinity of nuclear factor-κB (NF-κB). Ascochlorin down-regulates phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2) and p-p38[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ascochlorin Related Antibodies

Cell Viability Assay[3]

Cell Line: HepG2, HCCLM3, Huh7 cells
Concentration: 10, 25, 50 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibit the viability of three different HCC cell lines tested (HepG2, HCCLM3 and Huh7) in a time and dose dependent manner.

Western Blot Analysis[3]

Cell Line: HepG2 cells
Concentration: 50 μM
Incubation Time: 48 hours
Result: Inhibited expression of the cell cycle regulator protein cyclin D1, the anti-apoptotic proteins Bcl-2, Mcl-1, survivin and XIAP, and the invasive gene product MMP-9.
In Vivo

Ascochlorin (Ilicicolin D) (2.5-5 mg/kg; i.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31) inhibits tumor growth in an orthotopic HCC mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight week-old athymic balb/c nude female mice (HCCLM3-Luc2 tumors)[3]
Dosage: 2.5 mg/kg, 5 mg/kg
Administration: I.p.; day 0, 1, 2, 3, 13, 15, 17, 20, 22, 24, 27, 29 and 31
Result: Induced significant inhibition of tumor growth.
Molecular Weight

404.93

Formula

C23H29ClO4
CAS No.
SMILES

O=CC1=C(O)C(C/C=C(C)/C=C/[C@]2(C)[C@@H](C)C(CC[C@H]2C)=O)=C(O)C(Cl)=C1C
Structure Classification
Initial Source

Ascochyta viciae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ascochlorin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ascochlorin26166-39-2Ilicicolin DSTATApoptosisAntibioticCOX-2HepG2HCCcyclinviabilityathymicbalb/cnudemiceanti-inflammatorytumorInhibitorinhibitorinhibit

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