2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor
  4. Asenapine citrate

Asenapine citrate  (Synonyms: Org 5222 citrate)

Cat. No.: HY-10121B
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Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder.

For research use only. We do not sell to patients.

Asenapine citrate Chemical Structure

Asenapine citrate Chemical Structure

CAS No. : 1411867-74-7

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Asenapine citrate Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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α adrenergic receptor β adrenergic receptor

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • Biological Activity

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  • References

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Description

Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[1][2].

IC50 & Target

5-HT1B Receptor

8.4 (pKi)

5-HT1A Receptor

8.6 (pKi)

5-HT5 Receptor

8.8 (pKi)

5-HT6 Receptor

9.6 (pKi)

5-HT2B Receptor

9.8 (pKi)

5-HT7 Receptor

9.9 (pKi)

5-HT2A Receptor

10.2 (pKi)

5-HT2C Receptor

10.5 (pKi)

α1-adrenergic receptor

8.9 (pKi)

Alpha-2A adrenergic receptor

8.9 (pKi)

Alpha-2C adrenergic receptor

8.9 (pKi)

Alpha-2B adrenergic receptor

9.5 (pKi)

D1 Receptor

8.9 (pKi)

D2 Receptor

8.9 (pKi)

D4 Receptor

9.0 (pKi)

D3 Receptor

9.4 (pKi)

H2 Receptor

8.2 (pKi)

H1 Receptor

9.0 (pKi)

In Vivo

Asenapine (0.05-0.2 mg/kg; s.c.) induces a dose-dependent suppression of conditioned avoidance response (CAR) and does not induce catalepsy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

477.89

Formula

C23H24ClNO8
CAS No.
SMILES

ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1.O=C(CC(C(O)=O)(O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Asenapine citrate Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asenapine1411867-74-7Org 5222Org5222Org-52225-HT ReceptorDopamine ReceptorAdrenergic ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorpsychopharmacologicpsychopharmacologicaldopamineserotoninnoradrenalinenorepinephrinehistamineschizophreniabipolar disorderantidepressantInhibitorinhibitorinhibit

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