Aspirin-d₃ (Synonyms: Acetylsalicylic Acid-d₃; ASA-d₃)

Name: Aspirin-d 3
Brand: MedChemExpress
SKU: HY-14654S
Rating: 4.5 (1 reviews)

Cat. No.: HY-14654S Purity: 98.51%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aspirin-d₃ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.

For research use only. We do not sell to patients.

Aspirin-d<sub>3</sub> Chemical Structure

Aspirin-d₃ Chemical Structure

CAS No. : 921943-73-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 88	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 88	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 128	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 256	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 385	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Aspirin-d₃:

Aspirin In-stock
Aspirin-d₄ Get quote

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
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Description

Aspirin-d₃ is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

183.18

Formula

C₉H₅D₃O₄

CAS No.

921943-73-9

Unlabeled CAS

50-78-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=CC=C1OC(C([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (545.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4591 mL	27.2956 mL	54.5911 mL
5 mM	1.0918 mL	5.4591 mL	10.9182 mL
10 mM	0.5459 mL	2.7296 mL	5.4591 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.51%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (264 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.;Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.;Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.;Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.;Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	5.4591 mL	27.2956 mL	54.5911 mL	136.4778 mL
	5 mM	1.0918 mL	5.4591 mL	10.9182 mL	27.2956 mL
	10 mM	0.5459 mL	2.7296 mL	5.4591 mL	13.6478 mL
	15 mM	0.3639 mL	1.8197 mL	3.6394 mL	9.0985 mL
	20 mM	0.2730 mL	1.3648 mL	2.7296 mL	6.8239 mL
	25 mM	0.2184 mL	1.0918 mL	2.1836 mL	5.4591 mL
	30 mM	0.1820 mL	0.9099 mL	1.8197 mL	4.5493 mL
	40 mM	0.1365 mL	0.6824 mL	1.3648 mL	3.4119 mL
	50 mM	0.1092 mL	0.5459 mL	1.0918 mL	2.7296 mL
	60 mM	0.0910 mL	0.4549 mL	0.9099 mL	2.2746 mL
	80 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7060 mL
	100 mM	0.0546 mL	0.2730 mL	0.5459 mL	1.3648 mL

Aspirin-d₃ Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aspirin-d₃921943-73-9Acetylsalicylic Acid-d₃ASA-d₃COXAutophagyMitophagyVirus ProteaseCyclooxygenaseMitochondrial AutophagyInhibitorinhibitorinhibit

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Aspirin-d3 (Synonyms: Acetylsalicylic Acid-d3; ASA-d3)

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Complete Stock Solution Preparation Table

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Aspirin-d₃ (Synonyms: Acetylsalicylic Acid-d₃; ASA-d₃)

Other Forms of Aspirin-d₃:

Aspirin-d₃ Related Antibodies

Aspirin-d₃ Related Antibodies

Aspirin-d₃ Related Classifications