ATG12-ATG3 inhibitor 1

Cat. No.: HY-156966 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ATG12-ATG3 inhibitor 1 (compound 189) is a potent inhibitor of autophage.

For research use only. We do not sell to patients.

ATG12-ATG3 inhibitor 1 Chemical Structure

CAS No. : 333351-38-5

Size	Price	Stock	Quantity
5 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

ATG12-ATG3 inhibitor 1 (compound 189) is a potent inhibitor of autophage^[1].

Molecular Weight

327.40

Formula

C₁₈H₁₇NO₃S

CAS No.

333351-38-5

Appearance

Solid

Color

Light yellow to khaki

SMILES

O=S(NC1=CC=C(C2=C1C=CC=C2)O)(C3=CC=C(C)C=C3C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (763.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0544 mL	15.2718 mL	30.5437 mL
5 mM	0.6109 mL	3.0544 mL	6.1087 mL
10 mM	0.3054 mL	1.5272 mL	3.0544 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (256 KB) HNMR (248 KB) LCMS (84 KB)

Handling Instructions (2659 KB)

References

[1]. Gal Chaim Nuta, et al. Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction. Autophagy. 2023 Aug;19(8):2372-2385. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0544 mL	15.2718 mL	30.5437 mL	76.3592 mL
	5 mM	0.6109 mL	3.0544 mL	6.1087 mL	15.2718 mL
	10 mM	0.3054 mL	1.5272 mL	3.0544 mL	7.6359 mL
	15 mM	0.2036 mL	1.0181 mL	2.0362 mL	5.0906 mL
	20 mM	0.1527 mL	0.7636 mL	1.5272 mL	3.8180 mL
	25 mM	0.1222 mL	0.6109 mL	1.2217 mL	3.0544 mL
	30 mM	0.1018 mL	0.5091 mL	1.0181 mL	2.5453 mL
	40 mM	0.0764 mL	0.3818 mL	0.7636 mL	1.9090 mL
	50 mM	0.0611 mL	0.3054 mL	0.6109 mL	1.5272 mL
	60 mM	0.0509 mL	0.2545 mL	0.5091 mL	1.2727 mL
	80 mM	0.0382 mL	0.1909 mL	0.3818 mL	0.9545 mL
	100 mM	0.0305 mL	0.1527 mL	0.3054 mL	0.7636 mL