Atomoxetine-d3 hydrochloride

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Atomoxetine-d3 hydrochloride is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (K_i values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).

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Atomoxetine-d3 hydrochloride Chemical Structure

CAS No. : 1217776-38-9

Size	Price	Stock	Quantity
1 mg	USD 500	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Atomoxetine-d3 hydrochloride:

Atomoxetine Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description	Atomoxetine-d3 hydrochloride is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (K_i values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)^[1]^[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Atomoxetine-d3 hydrochloride Related Antibodies
Molecular Weight	294.83
Formula	C₁₇H₁₉D₃ClNO
CAS No.	1217776-38-9
Unlabeled CAS	82248-59-7
Appearance	Solid
Color	White to off-white
SMILES	CC(C=CC=C1)=C1O[C@@H](C2=CC=CC=C2)CCNC([2H])([2H])[2H].Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (289 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief] [2]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26. [Content Brief] [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [Content Brief]