2. Autophagy
  3. Autophagy
  4. Aumitin

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively.

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Aumitin Chemical Structure

Aumitin Chemical Structure

CAS No. : 946293-78-3

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 341 In-stock
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5 mg USD 310 In-stock
10 mg USD 465 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].

Molecular Weight

429.90

Formula

C24H20ClN5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3261 mL 11.6306 mL 23.2612 mL
5 mM 0.4652 mL 2.3261 mL 4.6522 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3261 mL 11.6306 mL 23.2612 mL 58.1531 mL
5 mM 0.4652 mL 2.3261 mL 4.6522 mL 11.6306 mL
10 mM 0.2326 mL 1.1631 mL 2.3261 mL 5.8153 mL
15 mM 0.1551 mL 0.7754 mL 1.5507 mL 3.8769 mL
20 mM 0.1163 mL 0.5815 mL 1.1631 mL 2.9077 mL
25 mM 0.0930 mL 0.4652 mL 0.9304 mL 2.3261 mL
30 mM 0.0775 mL 0.3877 mL 0.7754 mL 1.9384 mL
40 mM 0.0582 mL 0.2908 mL 0.5815 mL 1.4538 mL
50 mM 0.0465 mL 0.2326 mL 0.4652 mL 1.1631 mL
60 mM 0.0388 mL 0.1938 mL 0.3877 mL 0.9692 mL
80 mM 0.0291 mL 0.1454 mL 0.2908 mL 0.7269 mL
100 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5815 mL
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Aumitin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aumitin946293-78-3AutophagyInhibitorinhibitorinhibit

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