2. Apoptosis
  3. RIP kinase
  4. AV123

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.

For research use only. We do not sell to patients.

AV123 Chemical Structure

AV123 Chemical Structure

CAS No. : 233605-81-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 154 In-stock
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5 mg USD 140 In-stock
10 mg USD 220 In-stock
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Based on 1 publication(s) in Google Scholar

AV123 Related Antibodies

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RIPK1 RIPK2 RIPK3

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Description

AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].

IC50 & Target

IC50: 0.48 µM (CDK9/ CyclinT), 0.80 µM (CLK1 of Mus musculus), 1.80 µM (DYRK1A of Rattus norvegicus), >10 µM (CDK2/CyclinA, CDK5/p25, HASPIN, Pim1, CK1 ε, JAK3, ABL1, RIPK3, AURKB)[1].
In Vitro

AV123 (0.01-100 µM; 24 h) efficiently blocks necroptosis in a dose-dependent manner in FADD-deficient Jurkat cells[1].
AV123 (0.01-50 µM; 24 h) shows no toxicity to RPE-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AV123 Related Antibodies

Cell Viability Assay[1]

Cell Line: FADD-deficient Jurkat cells
Concentration: 0.01-100 µM
Incubation Time: 24 h
Result: Significantly blocked the necroptotic cell-death induced by TNF-α with an EC50 value of 1.7 µM.

Cell Cytotoxicity Assay[1]

Cell Line: RPE-1 cells
Concentration: 0.01-50 µM
Incubation Time: 24 h
Result: Exhibited no toxicity to RPE-1 cells.
Molecular Weight

234.25

Formula

C11H14N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (853.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2689 mL 21.3447 mL 42.6894 mL
5 mM 0.8538 mL 4.2689 mL 8.5379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2689 mL 21.3447 mL 42.6894 mL 106.7236 mL
5 mM 0.8538 mL 4.2689 mL 8.5379 mL 21.3447 mL
10 mM 0.4269 mL 2.1345 mL 4.2689 mL 10.6724 mL
15 mM 0.2846 mL 1.4230 mL 2.8460 mL 7.1149 mL
20 mM 0.2134 mL 1.0672 mL 2.1345 mL 5.3362 mL
25 mM 0.1708 mL 0.8538 mL 1.7076 mL 4.2689 mL
30 mM 0.1423 mL 0.7115 mL 1.4230 mL 3.5575 mL
40 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6681 mL
50 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1345 mL
60 mM 0.0711 mL 0.3557 mL 0.7115 mL 1.7787 mL
80 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
100 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
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AV123 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV123233605-81-7AV 123AV-123RIP kinaseReceptor-interacting protein kinasesRIPKnecroptosisFADD-deficient Jurkat cellsRPE-1 cellsRCDInhibitorinhibitorinhibit

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