2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. AY254

AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling

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AY254 Chemical Structure

AY254 Chemical Structure

CAS No. : 2093408-03-6

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AY254 Related Antibodies

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Description

AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling[1]

IC50 & Target

PAR2

2 nM (EC50)

Molecular Weight

631.77

Formula

C30H49N9O6
CAS No.
Sequence

{5-Isoxazolylcarbonyl-Cha}-{Chg}-Ala-Arg-NH2
Sequence Shortening

{5-Isoxazolylcarbonyl-Cha}-{Chg}-AR-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AY254 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AY2542093408-03-6AY 254AY-254Protease Activated Receptor (PAR)Thrombin receptorsbiasedAY77wound healingERK1/2 signalingInhibitorinhibitorinhibit

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