2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG4-NHS-ester

Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-NHS-ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG4-NHS-ester Chemical Structure

Azido-PEG4-NHS-ester Chemical Structure

CAS No. : 1807534-82-2

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25 mg USD 140 In-stock
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Based on 1 publication(s) in Google Scholar

Azido-PEG4-NHS-ester Related Antibodies

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Description

Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-NHS-ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG4-NHS-ester Related Antibodies
Molecular Weight

374.35

Formula

C14H22N4O8
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)COCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (267.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6713 mL 13.3565 mL 26.7130 mL
5 mM 0.5343 mL 2.6713 mL 5.3426 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

COA (242 KB) HNMR (248 KB) MS (67 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6713 mL 13.3565 mL 26.7130 mL 66.7824 mL
5 mM 0.5343 mL 2.6713 mL 5.3426 mL 13.3565 mL
10 mM 0.2671 mL 1.3356 mL 2.6713 mL 6.6782 mL
15 mM 0.1781 mL 0.8904 mL 1.7809 mL 4.4522 mL
20 mM 0.1336 mL 0.6678 mL 1.3356 mL 3.3391 mL
25 mM 0.1069 mL 0.5343 mL 1.0685 mL 2.6713 mL
30 mM 0.0890 mL 0.4452 mL 0.8904 mL 2.2261 mL
40 mM 0.0668 mL 0.3339 mL 0.6678 mL 1.6696 mL
50 mM 0.0534 mL 0.2671 mL 0.5343 mL 1.3356 mL
60 mM 0.0445 mL 0.2226 mL 0.4452 mL 1.1130 mL
80 mM 0.0334 mL 0.1670 mL 0.3339 mL 0.8348 mL
100 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.6678 mL
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Azido-PEG4-NHS-ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG4-NHS-ester1807534-82-2PROTAC LinkersInhibitorinhibitorinhibit

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