2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ42 agonist-2

Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells.

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Aβ42 agonist-2 Chemical Structure

Aβ42 agonist-2 Chemical Structure

CAS No. : 6314-40-5

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10 mg USD 48 In-stock
25 mg USD 85 In-stock
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Based on 1 publication(s) in Google Scholar

Aβ42 agonist-2 Related Antibodies

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Description

Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

IC50 & Target

Aβ42 aggregation[1]
Molecular Weight

253.32

Formula

C15H11NOS
CAS No.
Appearance

Solid

SMILES

O=C(C1=CC2=C(C=CC=C2)S1)NC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (493.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9476 mL 19.7379 mL 39.4758 mL
5 mM 0.7895 mL 3.9476 mL 7.8952 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9476 mL 19.7379 mL 39.4758 mL 98.6894 mL
5 mM 0.7895 mL 3.9476 mL 7.8952 mL 19.7379 mL
10 mM 0.3948 mL 1.9738 mL 3.9476 mL 9.8689 mL
15 mM 0.2632 mL 1.3159 mL 2.6317 mL 6.5793 mL
20 mM 0.1974 mL 0.9869 mL 1.9738 mL 4.9345 mL
25 mM 0.1579 mL 0.7895 mL 1.5790 mL 3.9476 mL
30 mM 0.1316 mL 0.6579 mL 1.3159 mL 3.2896 mL
40 mM 0.0987 mL 0.4934 mL 0.9869 mL 2.4672 mL
50 mM 0.0790 mL 0.3948 mL 0.7895 mL 1.9738 mL
60 mM 0.0658 mL 0.3290 mL 0.6579 mL 1.6448 mL
80 mM 0.0493 mL 0.2467 mL 0.4934 mL 1.2336 mL
100 mM 0.0395 mL 0.1974 mL 0.3948 mL 0.9869 mL
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Aβ42 agonist-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ42 agonist-26314-40-5Amyloid-ββ-amyloid peptideAβAbetaaggregation kineticsbeta-amyloidcell viabilityfibrillogenesisfluorescence imagingmolecular dockingsmall moleculestransmission electron microscopyInhibitorinhibitorinhibit

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