2. Others Membrane Transporter/Ion Channel Neuronal Signaling
  3. Isotope-Labeled Compounds Calcium Channel
  4. Barnidipine-d5 hydrochloride

Barnidipine-d5 hydrochloride  (Synonyms: Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride)

Cat. No.: HY-107322S Purity: ≥98.0%
SDS COA Handling Instructions

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Barnidipine-d5 (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].

For research use only. We do not sell to patients.

Barnidipine-d<sub>5</sub> hydrochloride Chemical Structure

Barnidipine-d5 hydrochloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Barnidipine-d5 hydrochloride:

Barnidipine-d5 hydrochloride Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Barnidipine-d5 (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1].Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].

IC50 & Target

L-type calcium channel

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Barnidipine-d5 hydrochloride Related Antibodies
Molecular Weight

533.03

Formula

C27H25D5ClN3O6
Unlabeled CAS

104757-53-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C([C@@H](C2=CC([N+]([O-])=O)=CC=C2)C(C(OC)=O)=C(N1)C)C(O[C@@H]3CN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (469.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8761 mL 9.3803 mL 18.7607 mL
5 mM 0.3752 mL 1.8761 mL 3.7521 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8761 mL 9.3803 mL 18.7607 mL 46.9017 mL
5 mM 0.3752 mL 1.8761 mL 3.7521 mL 9.3803 mL
10 mM 0.1876 mL 0.9380 mL 1.8761 mL 4.6902 mL
15 mM 0.1251 mL 0.6254 mL 1.2507 mL 3.1268 mL
20 mM 0.0938 mL 0.4690 mL 0.9380 mL 2.3451 mL
25 mM 0.0750 mL 0.3752 mL 0.7504 mL 1.8761 mL
30 mM 0.0625 mL 0.3127 mL 0.6254 mL 1.5634 mL
40 mM 0.0469 mL 0.2345 mL 0.4690 mL 1.1725 mL
50 mM 0.0375 mL 0.1876 mL 0.3752 mL 0.9380 mL
60 mM 0.0313 mL 0.1563 mL 0.3127 mL 0.7817 mL
80 mM 0.0235 mL 0.1173 mL 0.2345 mL 0.5863 mL
100 mM 0.0188 mL 0.0938 mL 0.1876 mL 0.4690 mL
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Barnidipine-d5 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Barnidipine-d5Mepirodipine-d5YM-09730-5-d5Isotope-Labeled CompoundsCalcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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