2. GPCR/G Protein
  3. GnRH Receptor
  4. BAY 1214784

BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids.

For research use only. We do not sell to patients.

BAY 1214784 Chemical Structure

BAY 1214784 Chemical Structure

CAS No. : 1631164-25-4

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5 mg USD 274 In-stock
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Description

BAY 1214784 is a potent, selective, and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R). BAY 1214784 is a spiroindoline derivative compound. BAY 1214784 effectively lowers plasma luteinizing hormone levels by up to 49%, at the same time being associated with low pharmacokinetic variability and good tolerability. BAY 1214784 has the potential for the research of uterine fibroids[1].

Molecular Weight

672.11

Formula

C29H26ClF4N3O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1[C@@](C2CC2)([H])C3(CCS(=O)(CC3)=O)C4=CC(C(NCC5=C(C=C(C=N5)C(F)(F)F)Cl)=O)=CC=C41)(C6=CC=C(C=C6)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 42 mg/mL (62.49 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4879 mL 7.4393 mL 14.8785 mL
5 mM 0.2976 mL 1.4879 mL 2.9757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.8%

SDS (251 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4879 mL 7.4393 mL 14.8785 mL 37.1963 mL
5 mM 0.2976 mL 1.4879 mL 2.9757 mL 7.4393 mL
10 mM 0.1488 mL 0.7439 mL 1.4879 mL 3.7196 mL
15 mM 0.0992 mL 0.4960 mL 0.9919 mL 2.4798 mL
20 mM 0.0744 mL 0.3720 mL 0.7439 mL 1.8598 mL
25 mM 0.0595 mL 0.2976 mL 0.5951 mL 1.4879 mL
30 mM 0.0496 mL 0.2480 mL 0.4960 mL 1.2399 mL
40 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9299 mL
50 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7439 mL
60 mM 0.0248 mL 0.1240 mL 0.2480 mL 0.6199 mL
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BAY 1214784 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 12147841631164-25-4BAY1214784BAY-1214784GnRH ReceptorGonadotropin releasing hormone receptorGNRHRselectiveoralhGnRH-Ruterine fibroidsspiroindoline derivativeInhibitorinhibitorinhibit

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