BChE-IN-4

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BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease.

For research use only. We do not sell to patients.

BChE-IN-4 Chemical Structure

CAS No. : 2304818-41-3

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Description

IC₅₀ & Target

BChE^[1]

In Vivo

BChE-IN-4 (compound 1) (10, 20, 30 mg/kg) attenuates learning and memory deficits caused by cholinergic deficit in AD mouse model^[1].
BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)^[1]
Dosage:	10, 20, 30 mg/kg
Administration:	I.p.
Result:	Significantly prolonged the step-through latencies in memory impaired mice.

Animal Model:	18-22 g, C57BL/6J mice^[1]
Dosage:	30 mg/kg
Administration:	I.p.
Result:	Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task.

Animal Model:	Mice^[1]
Dosage:	30 mg/kg (suspended in 1% Tween 80)
Administration:	I.p
Result:	Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test.

Molecular Weight

383.57

Formula

C₂₄H₃₇N₃O

CAS No.

2304818-41-3

SMILES

O=C(NCCC1CCCCCC1)[C@@H](NCCCC)CC2=CNC3=CC=CC=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Meden A, et al. Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors. Eur J Med Chem. 2020 Dec 15;208:112766. [Content Brief]

BChE-IN-4 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-42304818-41-3Cholinesterase (ChE)Alzheimer’s diseaselow cytotoxicitylearning and memory deficitsmotor effectsC57BL/6J micecross the blood-brain barrierInhibitorinhibitorinhibit

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