2. Inhibitory Antibodies
  3. Belatacept

Belatacept  (Synonyms: BMS 224818; LEA 29Y)

Cat. No.: HY-108813 Purity: 99.30%
SDS COA Technical Support

Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation.

For research use only. We do not sell to patients.

Belatacept Chemical Structure

Belatacept Chemical Structure

CAS No. : 706808-37-9

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Belatacept Related Antibodies

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Description

Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation[1][2].

IC50 & Target

CD80/86[1]
In Vitro

Belatacept (0-5 mg/mL, 1 h) inhibits T-cell proliferation in a dose-dependent manner[2].
Belatacept (500 ng/mL, 7 days) enhances predominance of effector-memory T-cells after allogeneic stimulation[2].
Belatacept (100, 500 ng/mL, 7 days) has no effect on differentiation and allogeneic IFNγ production of isolated effector-memory T cells[2].
Belatacept (10?μg/mL, 1 h) does not inhibit follicular T Cell-dependent B-Cell differentiation[4].
Belatacept (40?μg/mL, 10 days) reduces plasmablast differentiation, Ig production, and the major transcription factor Blimp-1 in a T cell-independent manner[5].
Belatacept (40?μg/mL, 30 min) induces activation of the STAT3 transcription factor in stimulated B cells and reduced the expression of CD86[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Belatacept Related Antibodies

Cell Viability Assay[2]

Cell Line: PBMCs from healthy volunteers
Concentration: 0-5 mg/mL
Incubation Time: 1 h
Result: Inhibited T-cell proliferation l with IC50 values of 215 ng/mL, and residual T-cell proliferation (±30%) was still present at high doses.

Western Blot Analysis[5]

Cell Line: CD40L and IL-21 stimulated B cells
Concentration: 40 μg/mL
Incubation Time: 15, 30 min
Result: Increased in STAT signaling determined by increased STAT3 phosphorylation.
In Vivo

Belatacept (intraperitoneal injection, 60 mg/kg) inhibits ABMR (Antibody-Mediated Rejection), and inhibits acute rejection when combined with BTLA (B and T lymphocyte attenuator) overexpression therapy[3].
Belatacept (intravenous injection, 20 mg/kg) displays immunosuppressive activities in monkeys immunized with sheep red blood cell[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute rejection model of orthotopic kidney transplantation in rats[3]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection, at postoperative and 4 days after transplantation.
Result: Inhibited creatinine increase after kidney transplantation (combined with BTLA overexpression therapy).
Reduced C4d in graft IF staining, and reduced CD138 infiltration and DSA production.
Animal Model: Rhesus monkeys immunized with sheep red blood cell[6]
Dosage: Intra-operatively 10 mg/kg, on day 4 (15 mg/kg) and on post-operative days 14, 28, 42, 56, 70 (20 mg/kg).
Administration: intravenous injection
Result: Caused a 50% reduction in the peak anti-SRBC response.
Prolonged renal allograft survival and synergies with conventional immunosuppression.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Belatacept]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.30%

SDS (251 KB)

COA (230 KB) SEC-HPLC (130 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Belatacept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belatacept706808-37-9BMS 224818 LEA 29YBMS224818BMS-224818OthersPBMCT-cellB cellseffector-memory T-cellskidney transplantationacute rejectionimmunosuppressantBTLAtransplantationInhibitorinhibitorinhibit

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