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  4. Bellidifolin

Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities. Bellidifolin also acts as a viral protein R (Vpr) inhibitor.

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Bellidifolin Chemical Structure

Bellidifolin Chemical Structure

CAS No. : 2798-25-6

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Based on 1 publication(s) in Google Scholar

Bellidifolin Related Antibodies

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Description

Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities[1][2][3]. Bellidifolin also acts as a viral protein R (Vpr) inhibitor[4].

Cellular Effect
Cell Line Type Value Description References
C6 IC50
> 100 μM
Compound: 7
Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay
Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay
[PMID: 18406151]
U-251 IC50
> 100 μM
Compound: 7
Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay
Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay
[PMID: 18406151]
Molecular Weight

274.23

Formula

C14H10O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(OC3=C1C(O)=CC=C3O)C=C(OC)C=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (182.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6466 mL 18.2329 mL 36.4657 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

SDS (393 KB)

COA (252 KB) HNMR (245 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6466 mL 18.2329 mL 36.4657 mL 91.1643 mL
5 mM 0.7293 mL 3.6466 mL 7.2931 mL 18.2329 mL
10 mM 0.3647 mL 1.8233 mL 3.6466 mL 9.1164 mL
15 mM 0.2431 mL 1.2155 mL 2.4310 mL 6.0776 mL
20 mM 0.1823 mL 0.9116 mL 1.8233 mL 4.5582 mL
25 mM 0.1459 mL 0.7293 mL 1.4586 mL 3.6466 mL
30 mM 0.1216 mL 0.6078 mL 1.2155 mL 3.0388 mL
40 mM 0.0912 mL 0.4558 mL 0.9116 mL 2.2791 mL
50 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.8233 mL
60 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
80 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
100 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.9116 mL
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Bellidifolin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bellidifolin2798-25-6HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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