2. Immunology/Inflammation
  3. IRAK Toll-like Receptor (TLR)
  4. BI1543673

BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS.

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BI1543673 Chemical Structure

BI1543673 Chemical Structure

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BI1543673 Related Antibodies

Top Publications Citing Use of Products

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IRAK1 IRAK4

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

BI1543673 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor. BI1543673 can reduce the inflammatory response stimulated by TLR4 and TLR7/8 in human lung tissue. BI1543673 can decrease inflammatory signaling in a mouse model of lung inflammation induced by LPS[1].
IC50 & Target

TLR4

 

TLR7

 

TLR8

 

Molecular Weight

515.65

Formula

C29H37N7O2
SMILES

CC1=CN2N=CC(C(NC3=NC4=C(N3CC(C)(O)C)C=CC([C@H]5CC[C@H](CC5)N6CCCC6)=C4)=O)=C2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BI1543673 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI1543673BI 1543673BI-1543673IRAKToll-like Receptor (TLR)Interleukin-1 receptor associated kinaseIL-1R associated kinaseIRAK4TLR4TLR7/8lung inflammationInhibitorinhibitorinhibit

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