2. Immunology/Inflammation
  3. IRAK
  4. BIO-7488

BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor with the IC50 of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively.

For research use only. We do not sell to patients.

BIO-7488 Chemical Structure

BIO-7488 Chemical Structure

CAS No. : 2573211-25-1

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BIO-7488 Related Antibodies

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IRAK1 IRAK4

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Description

BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor with the IC50 of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively[1].

IC50 & Target

hIRAK4

0.6 nM (IC50)

Molecular Weight

447.49

Formula

C23H25N7O3
CAS No.
SMILES

CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BIO-7488 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIO-74882573211-25-1BIO7488BIO 7488IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasestroketraumatic brain injuryInhibitorinhibitorinhibit

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