2. Immunology/Inflammation
  3. IRAK
  4. BIO-7488

BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor with the IC50 of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively.

For research use only. We do not sell to patients.

BIO-7488 Chemical Structure

BIO-7488 Chemical Structure

CAS No. : 2573211-25-1

Size Price Stock Quantity
5 mg USD 620 In-stock
10 mg USD 1020 In-stock
25 mg USD 2050 In-stock
50 mg USD 3350 In-stock
100 mg USD 5380 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BIO-7488 Related Antibodies

Top Publications Citing Use of Products

View All IRAK Isoform Specific Products:

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IRAK1 IRAK4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BIO-7488 is a potent, selective, oral active and CNS-penetrant IRAK4 inhibitor with the IC50 of 0.6 nM and > 30 μM for IRAK4 and hERG, respectively[1].

IC50 & Target

hIRAK4

0.6 nM (IC50)

Molecular Weight

447.49

Formula

C23H25N7O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (4.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2347 mL 11.1734 mL 22.3469 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2347 mL 11.1734 mL 22.3469 mL 55.8672 mL
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BIO-7488 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIO-74882573211-25-1BIO7488BIO 7488IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinasestroketraumatic brain injuryInhibitorinhibitorinhibit

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