Acute heart failure

Definition:

Acute heart failure (AHF) can be defined as a heterogeneous syndrome of signs and symptoms of new-onset or gradual/rapidly worsening heart failure (HF), requiring urgent therapy. Intrinsic cardiac abnormalities and comorbid conditions, including lung and renal disease, and sleep-disordered breathing, can contribute to the development of AHF. Factors triggering AHF may include ischemia, hypertension, arrhythmias, noncardiac comorbidities, and administered drugs, etc. Because of the poor clinical outcome and the relevant associated morbidity and mortality, it remains a major public health issue with a substantial socioeconomic burden.

References:

[1]. J Pöss, et al. Pharmacological treatment of acute heart failure: current treatment and new targets. Clin Pharmacol Ther. 2013 Oct;94(4):499-508. [Content Brief]

[2]. Piotr Ponikowski, et al. Pathogenesis and clinical presentation of acute heart failure. Rev Esp Cardiol (Engl Ed). 2015 Apr;68(4):331-7. [Content Brief]

[3]. Punam Chowdhury, et al. The use of biomarkers in the patient with heart failure. Curr Cardiol Rep. 2013 Jun;15(6):372. [Content Brief]

[4]. Robert J Mentz, et al. Pathophysiology and clinical evaluation of acute heart failure. Nat Rev Cardiol. 2016 Jan;13(1):28-35. [Content Brief]

[5]. Salvatore Di Somma, et al. Drug Therapy for Acute Heart Failure. Rev Esp Cardiol (Engl Ed). 2015 Aug;68(8):706-13. [Content Brief]

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